TY - JOUR
T1 - Antifungal and antibacterial activity of 3-alkylpyridinium polymeric analogs of marine toxins
AU - Zovko, Ana
AU - Vaukner Gabrič, Maja
AU - Sepčić, Kristina
AU - Pohleven, Franc
AU - Jaklič, Domen
AU - Gunde-Cimerman, Nina
AU - Lu, Zhibao
AU - Edrada-Ebel, Ruangelie
AU - Houssen, Wael E.
AU - Mancini, Ines
AU - Defant, Andrea
AU - Jaspars, Marcel
AU - Turk, Tom
PY - 2012/3
Y1 - 2012/3
N2 - Analogs of marine sponge-derived 3-alkylpyridinium compounds (3-APS) were synthesized and screened for possible antibacterial and antifungal activities. They were found to exhibit moderate antibacterial activity. Antifungal potential was tested on pathogenic fungus Candida albicans, baker's yeast Saccharomyces cerevisiae and hypersaline species Wallemia sebi. S. cerevisiae was the most susceptible to the action of selected 3-APS. Inhibitory effects on fungal growth were also studied on two wood-rotting fungi, brown-rot fungus Gloeophyllum trabeum and a white-rot fungus Trametes versicolor. The former showed a higher susceptibility to the action of 3-APS. The highest antifungal potential was observed with the poly-1,3-dodecyl pyridinium chloride (APS12-3, 7), while a complete loss of activity was noticed with the poly-1,3-butyl pyridinium chloride (APS3, 1), suggesting that this activity may closely correlate to the length of their alkyl chains. Based on our results, synthetic APS12-3 is a good candidate to be used as biocide or wood preservative against wood-rotting fungi.
AB - Analogs of marine sponge-derived 3-alkylpyridinium compounds (3-APS) were synthesized and screened for possible antibacterial and antifungal activities. They were found to exhibit moderate antibacterial activity. Antifungal potential was tested on pathogenic fungus Candida albicans, baker's yeast Saccharomyces cerevisiae and hypersaline species Wallemia sebi. S. cerevisiae was the most susceptible to the action of selected 3-APS. Inhibitory effects on fungal growth were also studied on two wood-rotting fungi, brown-rot fungus Gloeophyllum trabeum and a white-rot fungus Trametes versicolor. The former showed a higher susceptibility to the action of 3-APS. The highest antifungal potential was observed with the poly-1,3-dodecyl pyridinium chloride (APS12-3, 7), while a complete loss of activity was noticed with the poly-1,3-butyl pyridinium chloride (APS3, 1), suggesting that this activity may closely correlate to the length of their alkyl chains. Based on our results, synthetic APS12-3 is a good candidate to be used as biocide or wood preservative against wood-rotting fungi.
KW - antibacterial activity
KW - wood-decay fungi
KW - synthetic analogs
KW - alkylpyridinium compounds
KW - microwave-assisted polymerization
KW - antifungal activity
KW - 3-alkylpyridinium polymeric analogs
KW - marine toxins
UR - http://www.scopus.com/inward/record.url?scp=84856078058&partnerID=8YFLogxK
U2 - 10.1016/j.ibiod.2011.10.014
DO - 10.1016/j.ibiod.2011.10.014
M3 - Article
AN - SCOPUS:84856078058
SN - 0964-8305
VL - 68
SP - 71
EP - 77
JO - International Biodeterioration and Biodegradation
JF - International Biodeterioration and Biodegradation
ER -
