Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid

Saqib Ali, John Igoli, Carol Clements, Dima Semaan, Muhammad Almazeb, Mamoon-Ur Rashid, Syed Qaisar Shah, Valerie Ferro, Alexander Gray, M Rafiullah Khan

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13 Citations (Scopus)
162 Downloads (Pure)

Abstract

Methanol extracts of the roots of B. brevissima and B. parkeriana were examined for antidiabetic and antimicrobial activities. Six compounds i.e berberine, 8-oxo-berberine, dehydrocheilanthifoline, columbamine, jatrorrhizine and glutamic acid were isolated from the active fractions of these species for the first time. The antidiabetic activity was determined against Protein Tyrosine Phosphatase 1B (PTP 1B), a negative insulin regulator while the antimicrobial activity was performed against four bacterial strains: Mycobacterium marinum ATCC BAA535, sporadic Methicillin Resistant Staphylococcus aureus (SMRSA), endemic Methicillin Resistant Staphylococcus aureus (EMRSA) and Escherichia coli ATCC.8739 at different concentrations. Amongst the isolated compounds 8-oxo-berberine was found to be the most active antidiabetic (29 % of the positive control) while jatrorrhizine was the most active and selective antimicrobial against SMRSA and EMRSA (-1.2 % of the DMSO (D) control).
Original languageEnglish
Pages (from-to)336-342
Number of pages7
JournalBangladesh Journal of Pharmacology
Volume8
Issue number3
Early online date1 Aug 2013
DOIs
Publication statusPublished - 2013

Keywords

  • isoquinoline alkaloids
  • antidiabetic
  • antimicrobial
  • berberis brevissima
  • berberis parkeriana
  • fractions and compounds

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