Anti-microbial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

Rima W McLeod; Craig Roberts; Fiona Roberts; Jennifer Johnson; Michael Kirisits; David Ferguson; Russell Lyons; Ernest Mui; Roberts  Haselkorn; Doug Mack; Benjamin Samuel; Piotri Gornicki; Ellen Zuther

Anti-microbial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

Rima W McLeod (Inventor), Craig Roberts (Inventor), Fiona Roberts (Inventor), Jennifer Johnson (Inventor), Michael Kirisits (Inventor), David Ferguson (Inventor), Russell Lyons (Inventor), Ernest Mui (Inventor), Roberts Haselkorn (Inventor), Doug Mack (Inventor), Benjamin Samuel (Inventor), Piotri Gornicki (Inventor), Ellen Zuther (Inventor)

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Patent

Abstract

This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphorfructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors. A cDNA sequence that encodes chorismate synthase expressed at an early state of Apicomplexan development, is disclosed and may be altered to produce a 'knockout' organism useful in vaccine production.

Original language	English
Patent number	WO2000066154A3
Priority date	4/05/99
Publication status	Published - 15 Mar 2001

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title = "Anti-microbial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components",

abstract = "This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphorfructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors. A cDNA sequence that encodes chorismate synthase expressed at an early state of Apicomplexan development, is disclosed and may be altered to produce a 'knockout' organism useful in vaccine production.",

author = "McLeod, {Rima W} and Craig Roberts and Fiona Roberts and Jennifer Johnson and Michael Kirisits and David Ferguson and Russell Lyons and Ernest Mui and Roberts Haselkorn and Doug Mack and Benjamin Samuel and Piotri Gornicki and Ellen Zuther",

year = "2001",

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day = "15",

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TY - PAT

T1 - Anti-microbial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

AU - McLeod, Rima W

AU - Roberts, Craig

AU - Roberts, Fiona

AU - Johnson, Jennifer

AU - Kirisits, Michael

AU - Ferguson, David

AU - Lyons, Russell

AU - Mui, Ernest

AU - Haselkorn, Roberts

AU - Mack, Doug

AU - Samuel, Benjamin

AU - Gornicki, Piotri

AU - Zuther, Ellen

PY - 2001/3/15

Y1 - 2001/3/15

N2 - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphorfructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors. A cDNA sequence that encodes chorismate synthase expressed at an early state of Apicomplexan development, is disclosed and may be altered to produce a 'knockout' organism useful in vaccine production.

AB - This invention relates uses of components of plant-like metabolic pathways not including psbA or PPi phosphorfructokinase and not generally operative in animals or encoded by the plastid DNA, to develop compositions that interfere with Apicomplexan growth and survival. Components of the pathways include enzymes, transit peptides and nucleotide sequences encoding the enzymes and peptides, or promoters of these nucleotide sequences to which antibodies, antisense molecules and other inhibitors are directed. Diagnostic and therapeutic reagents and vaccines are developed based on the components and their inhibitors. A cDNA sequence that encodes chorismate synthase expressed at an early state of Apicomplexan development, is disclosed and may be altered to produce a 'knockout' organism useful in vaccine production.

M3 - Patent

M1 - WO2000066154A3

ER -

Anti-microbial agents, diagnostic reagents, and vaccines based on unique apicomplexan parasite components

Abstract

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