Anti-inflammatory and antipyretic activities of hygrophila spinosa t. anders leaves (acanthaceae)

A. Patra, S. Jha, P.N. Murthy, A.D. Vaibhav, P. Chattopadhyay, G. Panigrahi, D. Roy

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Purpose: Hygrophila spinosa T. Anders (Acanthaceae) is commonly used in the traditional system of medicine for the treatment of inflammation, pain, jaundice, rheumatism, arthritis, anaemia, etc. In the present study, we investigated the anti-inflammatory and antipyretic activities of the petroleum ether, chloroform, alcoholic and aqueous extracts of the leaf of this plant. Methods: The anti-inflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema in rats while antipyretic activity was evaluated on the basis of their effect on Brewer's yeast-induced pyrexia in rats. The extracts were screened for alkaloids, steroids, proteins, flavonoids, saponins, mucilage, carbohydrates, organic acids, fats and oils. Results: Preliminary phytochemical screening revealed the presence of alkaloids, steroids, proteins, flavonoids, fats and oils, tannins, mucilage and organic acids in the leaves of H. spinosa. Chloroform and alcoholic extracts of leaves of H. spinosa produced significant (p < 0.05 and p < 0.01) anti-inflammatory and antipyretic activities in a dose-dependent manner. On the other hand, petroleum ether and aqueous extracts did not show significant anti-inflammatory and antipyretic activities. The maximum anti-inflammatory activities produced by chloroform and alcoholic extracts (400 mg/kg) were 33.7% and 47.5%, respectively. These two extracts also reduced elevated body temperature in rats at 200 and 400 mg/kg body weight doses throughout the observation period of 6 h. Conclusion: Chloroform and alcoholic extracts of H. spinosa leaves have anti-inflammatory and antipyretic activities.
LanguageEnglish
Pages133-137
Number of pages4
JournalTropical Journal of Pharmaceutical Research
Volume8
Issue number2
Publication statusPublished - Apr 2009

Fingerprint

Acanthaceae
Antipyretics
Anti-Inflammatory Agents
Chloroform
Alkaloids
Flavonoids
Oils
Fats
Steroids
Acids
Plant Leaves
Carrageenan
Tannins
Saponins
Plant Extracts
Phytochemicals
Traditional Medicine
Systems Analysis
Jaundice
Rheumatic Diseases

Keywords

  • hygrophila spinosa
  • anti-inflammatory activity
  • antipyretic activity
  • leaf extracts

Cite this

Patra, A., Jha, S., Murthy, P. N., Vaibhav, A. D., Chattopadhyay, P., Panigrahi, G., & Roy, D. (2009). Anti-inflammatory and antipyretic activities of hygrophila spinosa t. anders leaves (acanthaceae). Tropical Journal of Pharmaceutical Research, 8(2), 133-137.
Patra, A. ; Jha, S. ; Murthy, P.N. ; Vaibhav, A.D. ; Chattopadhyay, P. ; Panigrahi, G. ; Roy, D. / Anti-inflammatory and antipyretic activities of hygrophila spinosa t. anders leaves (acanthaceae). In: Tropical Journal of Pharmaceutical Research. 2009 ; Vol. 8, No. 2. pp. 133-137.
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abstract = "Purpose: Hygrophila spinosa T. Anders (Acanthaceae) is commonly used in the traditional system of medicine for the treatment of inflammation, pain, jaundice, rheumatism, arthritis, anaemia, etc. In the present study, we investigated the anti-inflammatory and antipyretic activities of the petroleum ether, chloroform, alcoholic and aqueous extracts of the leaf of this plant. Methods: The anti-inflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema in rats while antipyretic activity was evaluated on the basis of their effect on Brewer's yeast-induced pyrexia in rats. The extracts were screened for alkaloids, steroids, proteins, flavonoids, saponins, mucilage, carbohydrates, organic acids, fats and oils. Results: Preliminary phytochemical screening revealed the presence of alkaloids, steroids, proteins, flavonoids, fats and oils, tannins, mucilage and organic acids in the leaves of H. spinosa. Chloroform and alcoholic extracts of leaves of H. spinosa produced significant (p < 0.05 and p < 0.01) anti-inflammatory and antipyretic activities in a dose-dependent manner. On the other hand, petroleum ether and aqueous extracts did not show significant anti-inflammatory and antipyretic activities. The maximum anti-inflammatory activities produced by chloroform and alcoholic extracts (400 mg/kg) were 33.7{\%} and 47.5{\%}, respectively. These two extracts also reduced elevated body temperature in rats at 200 and 400 mg/kg body weight doses throughout the observation period of 6 h. Conclusion: Chloroform and alcoholic extracts of H. spinosa leaves have anti-inflammatory and antipyretic activities.",
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Patra, A, Jha, S, Murthy, PN, Vaibhav, AD, Chattopadhyay, P, Panigrahi, G & Roy, D 2009, 'Anti-inflammatory and antipyretic activities of hygrophila spinosa t. anders leaves (acanthaceae)' Tropical Journal of Pharmaceutical Research, vol. 8, no. 2, pp. 133-137.

Anti-inflammatory and antipyretic activities of hygrophila spinosa t. anders leaves (acanthaceae). / Patra, A.; Jha, S.; Murthy, P.N.; Vaibhav, A.D.; Chattopadhyay, P.; Panigrahi, G.; Roy, D.

In: Tropical Journal of Pharmaceutical Research, Vol. 8, No. 2, 04.2009, p. 133-137.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Anti-inflammatory and antipyretic activities of hygrophila spinosa t. anders leaves (acanthaceae)

AU - Patra, A.

AU - Jha, S.

AU - Murthy, P.N.

AU - Vaibhav, A.D.

AU - Chattopadhyay, P.

AU - Panigrahi, G.

AU - Roy, D.

PY - 2009/4

Y1 - 2009/4

N2 - Purpose: Hygrophila spinosa T. Anders (Acanthaceae) is commonly used in the traditional system of medicine for the treatment of inflammation, pain, jaundice, rheumatism, arthritis, anaemia, etc. In the present study, we investigated the anti-inflammatory and antipyretic activities of the petroleum ether, chloroform, alcoholic and aqueous extracts of the leaf of this plant. Methods: The anti-inflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema in rats while antipyretic activity was evaluated on the basis of their effect on Brewer's yeast-induced pyrexia in rats. The extracts were screened for alkaloids, steroids, proteins, flavonoids, saponins, mucilage, carbohydrates, organic acids, fats and oils. Results: Preliminary phytochemical screening revealed the presence of alkaloids, steroids, proteins, flavonoids, fats and oils, tannins, mucilage and organic acids in the leaves of H. spinosa. Chloroform and alcoholic extracts of leaves of H. spinosa produced significant (p < 0.05 and p < 0.01) anti-inflammatory and antipyretic activities in a dose-dependent manner. On the other hand, petroleum ether and aqueous extracts did not show significant anti-inflammatory and antipyretic activities. The maximum anti-inflammatory activities produced by chloroform and alcoholic extracts (400 mg/kg) were 33.7% and 47.5%, respectively. These two extracts also reduced elevated body temperature in rats at 200 and 400 mg/kg body weight doses throughout the observation period of 6 h. Conclusion: Chloroform and alcoholic extracts of H. spinosa leaves have anti-inflammatory and antipyretic activities.

AB - Purpose: Hygrophila spinosa T. Anders (Acanthaceae) is commonly used in the traditional system of medicine for the treatment of inflammation, pain, jaundice, rheumatism, arthritis, anaemia, etc. In the present study, we investigated the anti-inflammatory and antipyretic activities of the petroleum ether, chloroform, alcoholic and aqueous extracts of the leaf of this plant. Methods: The anti-inflammatory activity of the various extracts was studied based on their effects on carrageenan-induced paw oedema in rats while antipyretic activity was evaluated on the basis of their effect on Brewer's yeast-induced pyrexia in rats. The extracts were screened for alkaloids, steroids, proteins, flavonoids, saponins, mucilage, carbohydrates, organic acids, fats and oils. Results: Preliminary phytochemical screening revealed the presence of alkaloids, steroids, proteins, flavonoids, fats and oils, tannins, mucilage and organic acids in the leaves of H. spinosa. Chloroform and alcoholic extracts of leaves of H. spinosa produced significant (p < 0.05 and p < 0.01) anti-inflammatory and antipyretic activities in a dose-dependent manner. On the other hand, petroleum ether and aqueous extracts did not show significant anti-inflammatory and antipyretic activities. The maximum anti-inflammatory activities produced by chloroform and alcoholic extracts (400 mg/kg) were 33.7% and 47.5%, respectively. These two extracts also reduced elevated body temperature in rats at 200 and 400 mg/kg body weight doses throughout the observation period of 6 h. Conclusion: Chloroform and alcoholic extracts of H. spinosa leaves have anti-inflammatory and antipyretic activities.

KW - hygrophila spinosa

KW - anti-inflammatory activity

KW - antipyretic activity

KW - leaf extracts

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M3 - Article

VL - 8

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EP - 137

JO - Tropical Journal of Pharmaceutical Research

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JF - Tropical Journal of Pharmaceutical Research

SN - 1596-5996

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ER -

Patra A, Jha S, Murthy PN, Vaibhav AD, Chattopadhyay P, Panigrahi G et al. Anti-inflammatory and antipyretic activities of hygrophila spinosa t. anders leaves (acanthaceae). Tropical Journal of Pharmaceutical Research. 2009 Apr;8(2):133-137.