Anti-infective activities of secondary metabolites from Vitex pinnata

Nurkhalida Kamal, Carol Clements, Alexander I. Gray, RuAngelie Edrada-Ebel

Research output: Contribution to journalArticle

Abstract

The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids ß-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4'-trimethoxyflavone (2), 5-hydroxy-7,4'-dimethoxy-flavone (3) and 5-hydroxy-3,3',4',7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.

LanguageEnglish
Pages102-106
Number of pages5
JournalJournal of Applied Pharmaceutical Science
Volume6
Issue number1
DOIs
Publication statusPublished - 26 Jan 2016

Fingerprint

flavone
Vitex
Mycobacterium marinum
Stigmasterol
Flavones
Trypanosoma brucei brucei
Phytochemicals
Flavonoids
Mass Spectrometry
Steroids
gamma-sitosterol

Keywords

  • anti-mycobacterial activity
  • antitrypanosomal activity
  • flavones
  • steroids
  • Vitex pinnata

Cite this

Kamal, Nurkhalida ; Clements, Carol ; Gray, Alexander I. ; Edrada-Ebel, RuAngelie. / Anti-infective activities of secondary metabolites from Vitex pinnata. In: Journal of Applied Pharmaceutical Science. 2016 ; Vol. 6, No. 1. pp. 102-106.
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Anti-infective activities of secondary metabolites from Vitex pinnata. / Kamal, Nurkhalida; Clements, Carol; Gray, Alexander I.; Edrada-Ebel, RuAngelie.

In: Journal of Applied Pharmaceutical Science, Vol. 6, No. 1, 26.01.2016, p. 102-106.

Research output: Contribution to journalArticle

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