Anti-infective activities of secondary metabolites from Vitex pinnata

Nurkhalida Kamal, Carol Clements, Alexander I. Gray, RuAngelie Edrada-Ebel

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Abstract

The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids ß-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4'-trimethoxyflavone (2), 5-hydroxy-7,4'-dimethoxy-flavone (3) and 5-hydroxy-3,3',4',7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalJournal of Applied Pharmaceutical Science
Volume6
Issue number1
DOIs
Publication statusPublished - 26 Jan 2016

Keywords

  • anti-mycobacterial activity
  • antitrypanosomal activity
  • flavones
  • steroids
  • Vitex pinnata

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