Abstract
The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids ß-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4'-trimethoxyflavone (2), 5-hydroxy-7,4'-dimethoxy-flavone (3) and 5-hydroxy-3,3',4',7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.
| Language | English |
|---|---|
| Pages | 102-106 |
| Number of pages | 5 |
| Journal | Journal of Applied Pharmaceutical Science |
| Volume | 6 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 26 Jan 2016 |
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Keywords
- anti-mycobacterial activity
- antitrypanosomal activity
- flavones
- steroids
- Vitex pinnata
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Anti-infective activities of secondary metabolites from Vitex pinnata. / Kamal, Nurkhalida; Clements, Carol; Gray, Alexander I.; Edrada-Ebel, RuAngelie.
In: Journal of Applied Pharmaceutical Science, Vol. 6, No. 1, 26.01.2016, p. 102-106.Research output: Contribution to journal › Article
TY - JOUR
T1 - Anti-infective activities of secondary metabolites from Vitex pinnata
AU - Kamal, Nurkhalida
AU - Clements, Carol
AU - Gray, Alexander I.
AU - Edrada-Ebel, RuAngelie
PY - 2016/1/26
Y1 - 2016/1/26
N2 - The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids ß-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4'-trimethoxyflavone (2), 5-hydroxy-7,4'-dimethoxy-flavone (3) and 5-hydroxy-3,3',4',7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.
AB - The phytochemical investigation of Vitex pinnata led to the isolation of a mixture of steroids ß-sitosterol and stigmasterol (1a and 1b) and three known flavonoid identified as 5-hydroxy-3, 7, 4'-trimethoxyflavone (2), 5-hydroxy-7,4'-dimethoxy-flavone (3) and 5-hydroxy-3,3',4',7-tetramethoxyflavone (4). The structures of all isolated compounds were carried out by NMR and mass spectrometry. The isolated compounds were evaluated for their anti-infective activities against Trypanosoma brucei brucei and Mycobacterium marinum. Compound 1-4 showed moderate antitrypanosomal activity with MIC values of 6.25μg/ml, 19.0, 21.0 and 17.0μM, respectively while no activity observed on anti-mycobacterial. This study is the first to report the presence of three flavones and their antitrypanosomal activity from V. pinnata.
KW - anti-mycobacterial activity
KW - antitrypanosomal activity
KW - flavones
KW - steroids
KW - Vitex pinnata
UR - http://www.scopus.com/inward/record.url?scp=84957691466&partnerID=8YFLogxK
UR - http://japsonline.com/index.php
U2 - 10.7324/JAPS.2016.600117
DO - 10.7324/JAPS.2016.600117
M3 - Article
VL - 6
SP - 102
EP - 106
JO - Journal of Applied Pharmaceutical Science
T2 - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
SN - 2231-3354
IS - 1
ER -