Anion recognition as a supramolecular switch of cell internalization

Jéssica Rodríguez; Jesús Mosquera; José R. Couceiro; Jonathan R. Nitschke; M. Eugenio Vázquez; José L. Mascareñas

doi:10.1021/jacs.6b11103

Anion recognition as a supramolecular switch of cell internalization

Jéssica Rodríguez, Jesús Mosquera, José R. Couceiro, Jonathan R. Nitschke, M. Eugenio Vázquez, José L. Mascareñas

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

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Abstract

The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	139
Issue number	1
Early online date	21 Dec 2016
DOIs	https://doi.org/10.1021/jacs.6b11103
Publication status	Published - 11 Jan 2017

Keywords

anions
peptides and proteins
fluorescence
encapsulation
imaging probes

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10.1021/jacs.6b11103

Rodríguez-etal-ACS2017-Anion-recognition-supramolecular-switch-cell-internalizationFinal published version, 3.92 MBLicence: Other

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AU - Vázquez, M. Eugenio

AU - Mascareñas, José L.

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KW - imaging probes

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Anion recognition as a supramolecular switch of cell internalization

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Keywords

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