Anion recognition as a supramolecular switch of cell internalization

Jéssica Rodríguez, Jesús Mosquera, José R. Couceiro, Jonathan R. Nitschke, M. Eugenio Vázquez, José L. Mascareñas

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)
2 Downloads (Pure)


The cell internalization of designed oligoarginine peptides equipped with six glutamic acid residues and an anionic pyranine at the N-terminus is triggered upon addition of a supramolecular host. This host binds specifically to the pyranine moiety, enabling the complex to traverse the cell membrane. Interestingly, none of the components, neither the host nor the guest, are able to cross the cell membrane on their own.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalJournal of the American Chemical Society
Issue number1
Early online date21 Dec 2016
Publication statusPublished - 11 Jan 2017


  • anions
  • peptides and proteins
  • fluorescence
  • encapsulation
  • imaging probes


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