Abstract
In animal cells, cytokinesis is characterised by the formation of the mitotic spindle that signals the assembly of an actomyosin ring between the spindle poles. Contraction of this ring drives ingression of the cleavage furrow, and culminates in the formation of a thin intercellular bridge between the daughter cells. At the centre of this bridge is the midbody, which is thought both to provide a site of attachment for the plasma membrane furrow and act as foci for the spatial and temporal control mechanisms that drive abscission. This review will focus upon recent studies that offer new insight into these events, in particular studies that elaborate on the mechanism of attachment between the furrow plasma membrane and the underlying cytoskeleton, and how dynamic changes in membrane composition might underpin key aspects of cytokinesis.
| Original language | English |
|---|---|
| Pages (from-to) | 64-73 |
| Number of pages | 10 |
| Journal | Seminars in Cell and Developmental Biology |
| Volume | 53 |
| Early online date | 23 Dec 2015 |
| DOIs | |
| Publication status | Published - 1 May 2016 |
Funding
Work in GWGs laboratory is supported by grants from Cancer Research UK (C25017/A9006 and A13082) and the Biotechnology and Biological Sciences Research Council. I thank Dr Saira N. Aslam for help in preparing the figures and Dr John Bett for helpful comments on the manuscript. GWG apologises to colleagues whose work was not cited as a consequence of space limitations.
Keywords
- abscission
- anillin
- centralspindlin
- cytokinesis
- ESCRT complex
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