Analyzing robustness of NF-kappaB signaling transduction networks via bifurcation analysis

Baoyun Lu, Hong Yue

Research output: Contribution to journalArticle

Abstract

Robustness is a widely observed and important property of biological systems. The nuclear factor-kB (NF-kB) signaling pathway is an important cellular signaling pathway that is involved in a variety of cellular processes including immune response, inflammation, and apoptosis. Oscillation is a common phenomenon in complex biological systems and it plays key roles in many cellular processes. Upon stimulation of TNFa, damped oscillations of NF-kB activity have been observed both experimentally and computationally in previous works. Bifurcation analysis has proven to be a powerful tool to identify the presence of complex behavior of dynamic systems. Based on a mathematical model of the TNFa mediated IkB-NF-kB signaling transduction pathway and also a simplified IkBα-NF-kB computational model with IkBβ and IkBε knock out, bifurcation analysis is performed to investigate the mechanism of biological robustness of the NF-kB signaling transduction pathway. In particular, we focused on the periodic solutions emerged via Hopf bifurcations and identified the parameter regions in which a stable periodic solution exists. Numerical study results confirm that IkBa is the key inhibitor of the NF-kB network and the cellular system has retained robustness even when some components are knocked out.
LanguageEnglish
Pages37-47
Number of pages11
JournalSystemics and Informatics World Network
Volume10
Publication statusPublished - 2010

Fingerprint

Network Analysis
Bifurcation Analysis
Robustness
Signaling Pathways
Biological Systems
Pathway
Periodic Solution
Oscillation
Inflammation
Apoptosis
Cellular Systems
Immune Response
Factor Models
Damped
Hopf Bifurcation
Computational Model
Inhibitor
Dynamic Systems
Numerical Study
Complex Systems

Keywords

  • robustness
  • bifurcation analysis
  • limit cycle oscillation
  • NF-kB signaling transduction pathway

Cite this

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Analyzing robustness of NF-kappaB signaling transduction networks via bifurcation analysis. / Lu, Baoyun; Yue, Hong.

In: Systemics and Informatics World Network, Vol. 10, 2010, p. 37-47.

Research output: Contribution to journalArticle

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T1 - Analyzing robustness of NF-kappaB signaling transduction networks via bifurcation analysis

AU - Lu, Baoyun

AU - Yue, Hong

PY - 2010

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