Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria

M.S. Webster, I. Timoshkin, S.J. MacGregor, R.A. Fouracre, M. Mattey

Research output: Contribution to conferencePaper

1 Citation (Scopus)

Abstract

An electrostatic finite element model of an interdigitated microelectrode array impedance biosensor has been used to further investigate the biosensor's sensitivity to detecting bacteria. Specifically, the sensor's sensitivity towards bacteria of different sizes was investigated and it was found that the biosensor was more sensitive to certain bacteria depending on their diameter. Further, it was discovered that by altering the sensor's physical wavelength, the sensor's topology can be optimized for the detection of a specific bacteria based on bacteria diameter. The effect of bacteria aggregation was also investigated. Increased aggregation i.e. increased numbers of bacteria on the sensor surface, eventually leads to sensor saturation and a maximum change in normalized capacitance can be estimated for a specific sensor topology. It is hoped that the modelling work presented here will aid in improved and knowledgeable development of the actual sensor for the rapid detection of bacteria.

Conference

ConferenceIEEE Conference on Electrical Insulation and Dielectric Phenomena, 2009
CountryUnited States
CityVirginia Beach
Period18/10/0921/10/09

Fingerprint

Biosensors
Bacteria
Sensors
Agglomeration
Topology
Microelectrodes
Electrostatics
Capacitance
Wavelength

Keywords

  • biological system modeling
  • biosensers
  • microelectrodes
  • microorganisms
  • microsensors
  • electric impedance measurement
  • finite element analysis
  • aggregation
  • bioMEMS

Cite this

Webster, M. S., Timoshkin, I., MacGregor, S. J., Fouracre, R. A., & Mattey, M. (2009). Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria. 19-22. Paper presented at IEEE Conference on Electrical Insulation and Dielectric Phenomena, 2009, Virginia Beach, United States. https://doi.org/10.1109/CEIDP.2009.5377785
Webster, M.S. ; Timoshkin, I. ; MacGregor, S.J. ; Fouracre, R.A. ; Mattey, M. / Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria. Paper presented at IEEE Conference on Electrical Insulation and Dielectric Phenomena, 2009, Virginia Beach, United States.4 p.
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title = "Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria",
abstract = "An electrostatic finite element model of an interdigitated microelectrode array impedance biosensor has been used to further investigate the biosensor's sensitivity to detecting bacteria. Specifically, the sensor's sensitivity towards bacteria of different sizes was investigated and it was found that the biosensor was more sensitive to certain bacteria depending on their diameter. Further, it was discovered that by altering the sensor's physical wavelength, the sensor's topology can be optimized for the detection of a specific bacteria based on bacteria diameter. The effect of bacteria aggregation was also investigated. Increased aggregation i.e. increased numbers of bacteria on the sensor surface, eventually leads to sensor saturation and a maximum change in normalized capacitance can be estimated for a specific sensor topology. It is hoped that the modelling work presented here will aid in improved and knowledgeable development of the actual sensor for the rapid detection of bacteria.",
keywords = "biological system modeling, biosensers, microelectrodes, microorganisms, microsensors, electric impedance measurement, finite element analysis, aggregation, bioMEMS",
author = "M.S. Webster and I. Timoshkin and S.J. MacGregor and R.A. Fouracre and M. Mattey",
year = "2009",
month = "10",
doi = "10.1109/CEIDP.2009.5377785",
language = "English",
pages = "19--22",
note = "IEEE Conference on Electrical Insulation and Dielectric Phenomena, 2009 ; Conference date: 18-10-2009 Through 21-10-2009",

}

Webster, MS, Timoshkin, I, MacGregor, SJ, Fouracre, RA & Mattey, M 2009, 'Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria' Paper presented at IEEE Conference on Electrical Insulation and Dielectric Phenomena, 2009, Virginia Beach, United States, 18/10/09 - 21/10/09, pp. 19-22. https://doi.org/10.1109/CEIDP.2009.5377785

Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria. / Webster, M.S.; Timoshkin, I.; MacGregor, S.J.; Fouracre, R.A.; Mattey, M.

2009. 19-22 Paper presented at IEEE Conference on Electrical Insulation and Dielectric Phenomena, 2009, Virginia Beach, United States.

Research output: Contribution to conferencePaper

TY - CONF

T1 - Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria

AU - Webster, M.S.

AU - Timoshkin, I.

AU - MacGregor, S.J.

AU - Fouracre, R.A.

AU - Mattey, M.

PY - 2009/10

Y1 - 2009/10

N2 - An electrostatic finite element model of an interdigitated microelectrode array impedance biosensor has been used to further investigate the biosensor's sensitivity to detecting bacteria. Specifically, the sensor's sensitivity towards bacteria of different sizes was investigated and it was found that the biosensor was more sensitive to certain bacteria depending on their diameter. Further, it was discovered that by altering the sensor's physical wavelength, the sensor's topology can be optimized for the detection of a specific bacteria based on bacteria diameter. The effect of bacteria aggregation was also investigated. Increased aggregation i.e. increased numbers of bacteria on the sensor surface, eventually leads to sensor saturation and a maximum change in normalized capacitance can be estimated for a specific sensor topology. It is hoped that the modelling work presented here will aid in improved and knowledgeable development of the actual sensor for the rapid detection of bacteria.

AB - An electrostatic finite element model of an interdigitated microelectrode array impedance biosensor has been used to further investigate the biosensor's sensitivity to detecting bacteria. Specifically, the sensor's sensitivity towards bacteria of different sizes was investigated and it was found that the biosensor was more sensitive to certain bacteria depending on their diameter. Further, it was discovered that by altering the sensor's physical wavelength, the sensor's topology can be optimized for the detection of a specific bacteria based on bacteria diameter. The effect of bacteria aggregation was also investigated. Increased aggregation i.e. increased numbers of bacteria on the sensor surface, eventually leads to sensor saturation and a maximum change in normalized capacitance can be estimated for a specific sensor topology. It is hoped that the modelling work presented here will aid in improved and knowledgeable development of the actual sensor for the rapid detection of bacteria.

KW - biological system modeling

KW - biosensers

KW - microelectrodes

KW - microorganisms

KW - microsensors

KW - electric impedance measurement

KW - finite element analysis

KW - aggregation

KW - bioMEMS

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Webster MS, Timoshkin I, MacGregor SJ, Fouracre RA, Mattey M. Analysis of the sensitivity of an impediometric biosensor for the detection of bacteria. 2009. Paper presented at IEEE Conference on Electrical Insulation and Dielectric Phenomena, 2009, Virginia Beach, United States. https://doi.org/10.1109/CEIDP.2009.5377785