Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming

L. Bicheiro, A.M. Morton, P. Garside, A.M. Mowat, M.M. Harnett

Research output: Contribution to journalArticlepeer-review


Peripheral tolerance plays an important role in preventing T lymphocyte responses to self or harmless antigens. One of the mechanisms that contributes to this form of tolerance is anergy, which is characterized by a lack of proliferation and IL-2 production by T cells in response to antigenic challenge. The acquisition of the anergic phenotype is an active process, with negative regulators of T cell signaling being induced. Among these are the E3 ubiquitin-protein ligases which recognize target proteins for ubiquitination and catalyze the transfer of ubiquitin to them, directing them to the proteasome or to the endosome-lysosomal pathway, and hence down-regulating their activity.
Original languageEnglish
Pages (from-to)128-128
Number of pages0
Issue numbers1
Publication statusPublished - Dec 2008


  • E3 ubiquitin-protein ligases
  • antigen-specific
  • CD4(+) t cells
  • immunology

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