Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming

L. Bicheiro, A.M. Morton, P. Garside, A.M. Mowat, M.M. Harnett

Research output: Contribution to journalArticle

Abstract

Peripheral tolerance plays an important role in preventing T lymphocyte responses to self or harmless antigens. One of the mechanisms that contributes to this form of tolerance is anergy, which is characterized by a lack of proliferation and IL-2 production by T cells in response to antigenic challenge. The acquisition of the anergic phenotype is an active process, with negative regulators of T cell signaling being induced. Among these are the E3 ubiquitin-protein ligases which recognize target proteins for ubiquitination and catalyze the transfer of ubiquitin to them, directing them to the proteasome or to the endosome-lysosomal pathway, and hence down-regulating their activity.
LanguageEnglish
Pages128-128
Number of pages0
JournalImmunology
Volume125
Issue numbers1
DOIs
Publication statusPublished - Dec 2008

Fingerprint

CD4 Antigens
Ubiquitin-Protein Ligases
T-Lymphocytes
Peripheral Tolerance
Ubiquitination
Endosomes
Proteasome Endopeptidase Complex
Ubiquitin
Interleukin-2
Phenotype
Antigens
Proteins

Keywords

  • E3 ubiquitin-protein ligases
  • antigen-specific
  • CD4(+) t cells
  • immunology

Cite this

Bicheiro, L. ; Morton, A.M. ; Garside, P. ; Mowat, A.M. ; Harnett, M.M. / Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming. In: Immunology. 2008 ; Vol. 125, No. s1. pp. 128-128.
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Analysis of E3 ubiquitin-protein ligases in antigen-specific CD4(+) T cells during tolerance and priming. / Bicheiro, L.; Morton, A.M.; Garside, P.; Mowat, A.M.; Harnett, M.M.

In: Immunology, Vol. 125, No. s1, 12.2008, p. 128-128.

Research output: Contribution to journalArticle

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