T-cell recognition of Ag can result in priming or tolerance depending on the context in which Ag is recognised. We have previously shown that both qualitative and quantitative differences in T-cell signalling underlie the differential outcomes of priming and tolerance of antigenspecific T-cells.
- ERK MAPK
- in vitro
- in vivo
Morton, A. M., Garside, P., Mowat, A. M., & Harnett, M. M. (2008). Analysing the role of ERK MAPK signalling and potential downstream cell cycle modulators in tolerance and priming of antigen-specific cd4(+) T-cells in vitro and in vivo. Immunology, 125(S1), 27-27. https://doi.org/10.1111/j.1365-2567.2008.02974.x