Analysing the role of ERK MAPK signalling and potential downstream cell cycle modulators in tolerance and priming of antigen-specific cd4(+) T-cells in vitro and in vivo

T-cell recognition of Ag can result in priming or tolerance depending on the context in which Ag is recognised. We have previously shown that both qualitative and quantitative differences in T-cell signalling underlie the differential outcomes of priming and tolerance of antigenspecific T-cells.