An update on the potential for male contraception: emerging options

Deborah A Garside, Ayman M Gebril, Manal Alsaadi, Natalie Nimmo, Alexander Mullen, Valerie Ferro

Research output: Contribution to journalArticle

Abstract

The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future.
LanguageEnglish
Number of pages11
JournalOpen Access Journal of Contraception
Volume2013
Issue number4
DOIs
Publication statusPublished - 11 Apr 2013

Fingerprint

Immunologic Contraception
Contraception
Spermatozoa
Vasectomy
Plant Extracts
Condoms
Spermatogenesis
Contraceptive Agents
Tretinoin
MicroRNAs
Epigenomics
Protein Kinases
Opioid Analgesics
Testosterone
Proteins
Population

Keywords

  • contraception
  • male contraception
  • nonhormonal contraceptives
  • hormonal
  • immunocontraception

Cite this

@article{da8b7ba1a58c45c99f72420dbb01bbbe,
title = "An update on the potential for male contraception: emerging options",
abstract = "The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future.",
keywords = "contraception, male contraception, nonhormonal contraceptives, hormonal, immunocontraception",
author = "Garside, {Deborah A} and Gebril, {Ayman M} and Manal Alsaadi and Natalie Nimmo and Alexander Mullen and Valerie Ferro",
year = "2013",
month = "4",
day = "11",
doi = "10.2147/OAJC.S30380",
language = "English",
volume = "2013",
journal = "Open Access Journal of Contraception",
issn = "1179-1527",
number = "4",

}

An update on the potential for male contraception : emerging options. / Garside, Deborah A; Gebril, Ayman M; Alsaadi, Manal; Nimmo, Natalie; Mullen, Alexander; Ferro, Valerie.

In: Open Access Journal of Contraception, Vol. 2013, No. 4, 11.04.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An update on the potential for male contraception

T2 - Open Access Journal of Contraception

AU - Garside, Deborah A

AU - Gebril, Ayman M

AU - Alsaadi, Manal

AU - Nimmo, Natalie

AU - Mullen, Alexander

AU - Ferro, Valerie

PY - 2013/4/11

Y1 - 2013/4/11

N2 - The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future.

AB - The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women. Current options available to men include withdrawal, condoms, and vasectomy. Methods in development fall into two categories: hormonal and nonhormonal. This review will provide an overview of the testosterone combinations and immunocontraception of hormonal targets. Nonhormonal immunocontraception of sperm proteins will also be examined, together with the use of agents to disrupt other sperm-associated targets and pathways. The categories focused on include epididymal proteins, testicular kinases, epigenetic reader proteins, opioids, lonidamine derivatives, retinoic acid, microRNAs associated with spermatogenesis, and plant extracts. Considering these developments, the number of options available to men is likely to increase in the near future.

KW - contraception

KW - male contraception

KW - nonhormonal contraceptives

KW - hormonal

KW - immunocontraception

UR - http://www.dovepress.com/open-access-journal-of-contraception-journal

U2 - 10.2147/OAJC.S30380

DO - 10.2147/OAJC.S30380

M3 - Article

VL - 2013

JO - Open Access Journal of Contraception

JF - Open Access Journal of Contraception

SN - 1179-1527

IS - 4

ER -