An investigation into the effect of cimetidine pre-treatment on raft formation of an anti-reflux agent

N. Washington, C.G. Wilson, D.L. Williams, C. Robertson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

It is now becoming common practice to co-administer H2 receptor antagonists and anti-reflux agents in the treatment of reflux oesophagitis. The mechanism by which anti-reflux agents achieve flotation requires a small amount of gastric acid to be present in the stomach. This study investigated whether an antireflux agent would remain effective after the decrease in acid secretion produced by a typical clinical dosage regimen of cimetidine (400 mg q.d.s., 7 days). Gastric distribution and residence of a meal and an anti-reflux agent were assessed in 12 normal subjects using gamma scintigraphy. The area under the gastric and fundal emptying curves demonstrated that Liquid Gaviscon (sodium alginate compound) had a significantly greater gastric residence than the meal, both during the control period and after cimetidine pre-treatment, and that the majority of the Gaviscon was located in the fundus. The distribution of Gaviscon into the fundus was not affected by cimetidine pre-treatment. Cimetidine pre-treatment slightly, but not significantly, increased the time for half the meal and the Gaviscon to empty from the stomach. The results suggest that the mechanism of action of Liquid Gaviscon is not compromised by concurrent H2-antagonist therapy.
LanguageEnglish
Pages553-559
Number of pages6
JournalAlimentary Pharmacology and Therapeutics
Volume7
Issue number5
Publication statusPublished - Oct 1993

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Cimetidine
Stomach
Meals
Sodium Compounds
Peptic Esophagitis
Histamine H2 Receptors
Gastric Emptying
Gastric Acid
Radionuclide Imaging
alginate, aluminium hydroxide, magnesium trisilicate, sodium bicarbonate drug combination
Acids

Keywords

  • symptomatic gastroesophageal refulx
  • gastric acid secretion
  • active duodenal ulcer
  • esophagitis
  • antacids

Cite this

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abstract = "It is now becoming common practice to co-administer H2 receptor antagonists and anti-reflux agents in the treatment of reflux oesophagitis. The mechanism by which anti-reflux agents achieve flotation requires a small amount of gastric acid to be present in the stomach. This study investigated whether an antireflux agent would remain effective after the decrease in acid secretion produced by a typical clinical dosage regimen of cimetidine (400 mg q.d.s., 7 days). Gastric distribution and residence of a meal and an anti-reflux agent were assessed in 12 normal subjects using gamma scintigraphy. The area under the gastric and fundal emptying curves demonstrated that Liquid Gaviscon (sodium alginate compound) had a significantly greater gastric residence than the meal, both during the control period and after cimetidine pre-treatment, and that the majority of the Gaviscon was located in the fundus. The distribution of Gaviscon into the fundus was not affected by cimetidine pre-treatment. Cimetidine pre-treatment slightly, but not significantly, increased the time for half the meal and the Gaviscon to empty from the stomach. The results suggest that the mechanism of action of Liquid Gaviscon is not compromised by concurrent H2-antagonist therapy.",
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An investigation into the effect of cimetidine pre-treatment on raft formation of an anti-reflux agent. / Washington, N.; Wilson, C.G.; Williams, D.L.; Robertson, C.

In: Alimentary Pharmacology and Therapeutics , Vol. 7, No. 5, 10.1993, p. 553-559.

Research output: Contribution to journalArticle

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