An investigation into the compatibility of 5 potential binders for the production of artificial bone scaffolds

April Dunham, Xiu Yan, Mary Grant

Research output: Contribution to conferenceAbstract

Abstract

Current practice of facial reconstruction is often below patients’ expectations. This could be improved by the use of 3D printed personalised bone scaffolds. In this study the biocompatibility of 5 potential binders for this process was investigated in vitro. None of the binders showed an overt toxic effect. However, all potential
binders except for sodium trisilicate solution showed a cytostatic effect at concentrations of 100µM suggesting their use could result in an inhibitory affect on wound healing in vivo.
Original languageEnglish
Pages26
Number of pages1
Publication statusPublished - 2011
EventBritish Toxicology Society Meeting - Nottingham, United Kingdom
Duration: 5 Sep 20116 Sep 2011

Conference

ConferenceBritish Toxicology Society Meeting
CountryUnited Kingdom
CityNottingham
Period5/09/116/09/11

Fingerprint

Poisons
Cytostatic Agents
Wound Healing
Sodium
Bone and Bones
In Vitro Techniques

Keywords

  • artificial bone scaffolds
  • bioengineering
  • facial reconstruction

Cite this

Dunham, A., Yan, X., & Grant, M. (2011). An investigation into the compatibility of 5 potential binders for the production of artificial bone scaffolds. 26. Abstract from British Toxicology Society Meeting, Nottingham, United Kingdom.
Dunham, April ; Yan, Xiu ; Grant, Mary. / An investigation into the compatibility of 5 potential binders for the production of artificial bone scaffolds. Abstract from British Toxicology Society Meeting, Nottingham, United Kingdom.1 p.
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Dunham, A, Yan, X & Grant, M 2011, 'An investigation into the compatibility of 5 potential binders for the production of artificial bone scaffolds' British Toxicology Society Meeting, Nottingham, United Kingdom, 5/09/11 - 6/09/11, pp. 26.

An investigation into the compatibility of 5 potential binders for the production of artificial bone scaffolds. / Dunham, April; Yan, Xiu; Grant, Mary.

2011. 26 Abstract from British Toxicology Society Meeting, Nottingham, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - An investigation into the compatibility of 5 potential binders for the production of artificial bone scaffolds

AU - Dunham, April

AU - Yan, Xiu

AU - Grant, Mary

PY - 2011

Y1 - 2011

N2 - Current practice of facial reconstruction is often below patients’ expectations. This could be improved by the use of 3D printed personalised bone scaffolds. In this study the biocompatibility of 5 potential binders for this process was investigated in vitro. None of the binders showed an overt toxic effect. However, all potential binders except for sodium trisilicate solution showed a cytostatic effect at concentrations of 100µM suggesting their use could result in an inhibitory affect on wound healing in vivo.

AB - Current practice of facial reconstruction is often below patients’ expectations. This could be improved by the use of 3D printed personalised bone scaffolds. In this study the biocompatibility of 5 potential binders for this process was investigated in vitro. None of the binders showed an overt toxic effect. However, all potential binders except for sodium trisilicate solution showed a cytostatic effect at concentrations of 100µM suggesting their use could result in an inhibitory affect on wound healing in vivo.

KW - artificial bone scaffolds

KW - bioengineering

KW - facial reconstruction

UR - http://www.pgbiomed2011.com/session22.html

UR - http://www.robots.ox.ac.uk/~davidc/pubs/pgbiomed_proc2011.pdf

M3 - Abstract

SP - 26

ER -

Dunham A, Yan X, Grant M. An investigation into the compatibility of 5 potential binders for the production of artificial bone scaffolds. 2011. Abstract from British Toxicology Society Meeting, Nottingham, United Kingdom.