As the readership of this journal understands, extracellular nucleotides, such as ATP, act via P2X and P2Y receptors to elicit many physiological and pathophysiological actions and roles throughout the body. A variety of mechanisms have been discovered and characterised by which cells can release intracellular nucleotides. This special issue of Purinergic Signalling — "The contribution of pannexin-1, connexins and CALHM ATP-release channels to purinergic signalling", assembled by myself and Nick Dale, focusses on large pore, transmembrane channels that are permeable to ATP and so enable it to act as an autocrine and paracrine signalling molecule.
- purinergic signalling
- cell type