An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis

Marine Vallet; Quentin P. Vanbellingen; Tingting Fu; Jean-Pierre Le Caer; Serge Della-Negra; David Touboul; Katherine R. Duncan; Bastien Nay; Alain Brunelle; Soizic Prado

doi:10.1021/acs.jnatprod.6b01185

An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis

Marine Vallet, Quentin P. Vanbellingen, Tingting Fu, Jean-Pierre Le Caer, Serge Della-Negra, David Touboul, Katherine R. Duncan, Bastien Nay, Alain Brunelle, Soizic Prado

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article

6 Citations (Scopus)

13 Downloads (Pure)

Abstract

An integrative approach combining traditional natural products chemistry, molecular networking, and mass spectrometry imaging has been undertaken to decipher the molecular dialogue between the fungus Paraconiothyrium variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis. From this study, we highlight that bacterial surfactins and a fungal tetronic acid are involved in such competition and that the fungus is able to hydrolyze surfactins to fight against the bacterial partner.

Original language	English
Pages (from-to)	2863–2873
Number of pages	11
Journal	Journal of Natural Products
Volume	80
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.6b01185
Publication status	Published - 15 Nov 2017

Fingerprint

Endophytes

Bacilli

Bacillus subtilis

Fungi

Cephalotaxus

Antibiosis

Coniferophyta

Biological Products

Mass spectrometry

Mass Spectrometry

Bacteria

Imaging techniques

tetronic acid

Keywords

molecular dialogue
fungus
bacterium
Paraconiothyrium variabile
Bacillus subtilis
antibiosis

Cite this

Vallet, M., Vanbellingen, Q. P., Fu, T., Le Caer, J-P., Della-Negra, S., Touboul, D., ... Prado, S. (2017). An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis. Journal of Natural Products, 80(11), 2863–2873. https://doi.org/10.1021/acs.jnatprod.6b01185

Vallet, Marine ; Vanbellingen, Quentin P. ; Fu, Tingting ; Le Caer, Jean-Pierre ; Della-Negra, Serge ; Touboul, David ; Duncan, Katherine R. ; Nay, Bastien ; Brunelle, Alain ; Prado, Soizic. / An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis. In: Journal of Natural Products. 2017 ; Vol. 80, No. 11. pp. 2863–2873.

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abstract = "An integrative approach combining traditional natural products chemistry, molecular networking, and mass spectrometry imaging has been undertaken to decipher the molecular dialogue between the fungus Paraconiothyrium variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis. From this study, we highlight that bacterial surfactins and a fungal tetronic acid are involved in such competition and that the fungus is able to hydrolyze surfactins to fight against the bacterial partner.",

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author = "Marine Vallet and Vanbellingen, {Quentin P.} and Tingting Fu and {Le Caer}, Jean-Pierre and Serge Della-Negra and David Touboul and Duncan, {Katherine R.} and Bastien Nay and Alain Brunelle and Soizic Prado",

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Vallet, M, Vanbellingen, QP, Fu, T, Le Caer, J-P, Della-Negra, S, Touboul, D, Duncan, KR, Nay, B, Brunelle, A & Prado, S 2017, 'An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis', Journal of Natural Products, vol. 80, no. 11, pp. 2863–2873. https://doi.org/10.1021/acs.jnatprod.6b01185

An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis. / Vallet, Marine; Vanbellingen, Quentin P.; Fu, Tingting; Le Caer, Jean-Pierre; Della-Negra, Serge; Touboul, David; Duncan, Katherine R.; Nay, Bastien; Brunelle, Alain; Prado, Soizic.

In: Journal of Natural Products, Vol. 80, No. 11, 15.11.2017, p. 2863–2873.

Research output: Contribution to journal › Article

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AU - Fu, Tingting

AU - Le Caer, Jean-Pierre

AU - Della-Negra, Serge

AU - Touboul, David

AU - Duncan, Katherine R.

AU - Nay, Bastien

AU - Brunelle, Alain

AU - Prado, Soizic

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KW - fungus

KW - bacterium

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