An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis

Marine Vallet, Quentin P. Vanbellingen, Tingting Fu, Jean-Pierre Le Caer, Serge Della-Negra, David Touboul, Katherine R. Duncan, Bastien Nay, Alain Brunelle, Soizic Prado

Research output: Contribution to journalArticle

9 Citations (Scopus)
15 Downloads (Pure)

Abstract

An integrative approach combining traditional natural products chemistry, molecular networking, and mass spectrometry imaging has been undertaken to decipher the molecular dialogue between the fungus Paraconiothyrium variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis. From this study, we highlight that bacterial surfactins and a fungal tetronic acid are involved in such competition and that the fungus is able to hydrolyze surfactins to fight against the bacterial partner.
Original languageEnglish
Pages (from-to)2863–2873
Number of pages11
JournalJournal of Natural Products
Volume80
Issue number11
DOIs
Publication statusPublished - 15 Nov 2017

Keywords

  • molecular dialogue
  • fungus
  • bacterium
  • Paraconiothyrium variabile
  • Bacillus subtilis
  • antibiosis

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