An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis

Marine Vallet, Quentin P. Vanbellingen, Tingting Fu, Jean-Pierre Le Caer, Serge Della-Negra, David Touboul, Katherine R. Duncan, Bastien Nay, Alain Brunelle, Soizic Prado

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

An integrative approach combining traditional natural products chemistry, molecular networking, and mass spectrometry imaging has been undertaken to decipher the molecular dialogue between the fungus Paraconiothyrium variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis. From this study, we highlight that bacterial surfactins and a fungal tetronic acid are involved in such competition and that the fungus is able to hydrolyze surfactins to fight against the bacterial partner.
LanguageEnglish
Pages2863–2873
Number of pages11
JournalJournal of Natural Products
Volume80
Issue number11
DOIs
Publication statusPublished - 15 Nov 2017

Fingerprint

Endophytes
Bacilli
Bacillus subtilis
Fungi
Cephalotaxus
Antibiosis
Coniferophyta
Biological Products
Mass spectrometry
Mass Spectrometry
Bacteria
Imaging techniques
tetronic acid

Keywords

  • molecular dialogue
  • fungus
  • bacterium
  • Paraconiothyrium variabile
  • Bacillus subtilis
  • antibiosis

Cite this

Vallet, Marine ; Vanbellingen, Quentin P. ; Fu, Tingting ; Le Caer, Jean-Pierre ; Della-Negra, Serge ; Touboul, David ; Duncan, Katherine R. ; Nay, Bastien ; Brunelle, Alain ; Prado, Soizic. / An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis. In: Journal of Natural Products. 2017 ; Vol. 80, No. 11. pp. 2863–2873.
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Vallet, M, Vanbellingen, QP, Fu, T, Le Caer, J-P, Della-Negra, S, Touboul, D, Duncan, KR, Nay, B, Brunelle, A & Prado, S 2017, 'An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis' Journal of Natural Products, vol. 80, no. 11, pp. 2863–2873. https://doi.org/10.1021/acs.jnatprod.6b01185

An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis. / Vallet, Marine; Vanbellingen, Quentin P.; Fu, Tingting; Le Caer, Jean-Pierre; Della-Negra, Serge; Touboul, David; Duncan, Katherine R.; Nay, Bastien; Brunelle, Alain; Prado, Soizic.

In: Journal of Natural Products, Vol. 80, No. 11, 15.11.2017, p. 2863–2873.

Research output: Contribution to journal › Article

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AU - Vallet, Marine

AU - Vanbellingen, Quentin P.

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AU - Le Caer, Jean-Pierre

AU - Della-Negra, Serge

AU - Touboul, David

AU - Duncan, Katherine R.

AU - Nay, Bastien

AU - Brunelle, Alain

AU - Prado, Soizic

PY - 2017/11/15

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AB - An integrative approach combining traditional natural products chemistry, molecular networking, and mass spectrometry imaging has been undertaken to decipher the molecular dialogue between the fungus Paraconiothyrium variabile and the bacterium Bacillus subtilis, which were isolated as endophytes from the conifer Cephalotaxus harringtonia and are characterized by a strong and mutual antibiosis. From this study, we highlight that bacterial surfactins and a fungal tetronic acid are involved in such competition and that the fungus is able to hydrolyze surfactins to fight against the bacterial partner.

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KW - fungus

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Vallet M, Vanbellingen QP, Fu T, Le Caer J-P, Della-Negra S, Touboul D et al. An integrative approach to decipher the chemical antagonism between the competing endophytes paraconiothyrium variabile and Bacillus subtilis. Journal of Natural Products. 2017 Nov 15;80(11):2863–2873. https://doi.org/10.1021/acs.jnatprod.6b01185

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