An in vitro system for the study of ultrasound contrast agents using a commercial imaging system

V. Sboros, C. Moran, T. Anderson, L. Gatzoulis, A. Criton, M. Averkiou, S. Pye, N. McDicken

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An in vitro system for the investigation of the behaviour of contrast microbubbles in an ultrasound field, that provides a full diagnostic range of settings, is yet to be presented in the literature. The evaluation of a good compromise of such a system is presented in this paper. It is based on (a) an HDI3000 ATL scanner (Bothell, WA, USA) externally controlled by a PC and (b) on the use of well-defined reference materials. The suspensions of the reference ultrasonic scattering material are placed in an anechoic tank. The pulse length ranges from 2 to 10 cycles, the acoustic pressure from 0.08 to 1.8 MPa, the transmit frequency from 1 to 4.3 MHz, and the receive frequency from 1 to 8 MHz. The collection of 256 samples of RF data, at an offset distance from the transducer face, was performed at 20 MHz digitization rate, which corresponds to approximately 1 cm depth in water. Two particle suspensions are also presented for use as reference scatterers for contrast studies: (a) a suspension of Orgasol® (ELF Atochem, Paris, France) particles (~5 μm mean diameter) and (b) a suspension of Eccosphere® (New Metals & Chemicals Ltd, Essex, UK) particles (~50 μm mean diameter). A preliminary experiment with the contrast agent Definity (DuPont Pharmaceutical Co, Waltham, MA) showed that the above two materials are suitable for use as a reference for contrast backscatter.
LanguageEnglish
Pages3301-3321
Number of pages20
JournalPhysics in Medicine and Biology
Volume46
Issue number12
DOIs
Publication statusPublished - 2001

Fingerprint

Contrast Media
Suspensions
Microbubbles
Paris
Transducers
Acoustics
Ultrasonics
France
Metals
Pressure
In Vitro Techniques
Water
Pharmaceutical Preparations

Keywords

  • ultrasound
  • imaging
  • in vitro system
  • physics
  • medicine

Cite this

Sboros, V., Moran, C., Anderson, T., Gatzoulis, L., Criton, A., Averkiou, M., ... McDicken, N. (2001). An in vitro system for the study of ultrasound contrast agents using a commercial imaging system. Physics in Medicine and Biology, 46(12), 3301-3321. https://doi.org/10.1088/0031-9155/46/12/316
Sboros, V. ; Moran, C. ; Anderson, T. ; Gatzoulis, L. ; Criton, A. ; Averkiou, M. ; Pye, S. ; McDicken, N. / An in vitro system for the study of ultrasound contrast agents using a commercial imaging system. In: Physics in Medicine and Biology. 2001 ; Vol. 46, No. 12. pp. 3301-3321.
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Sboros, V, Moran, C, Anderson, T, Gatzoulis, L, Criton, A, Averkiou, M, Pye, S & McDicken, N 2001, 'An in vitro system for the study of ultrasound contrast agents using a commercial imaging system' Physics in Medicine and Biology, vol. 46, no. 12, pp. 3301-3321. https://doi.org/10.1088/0031-9155/46/12/316

An in vitro system for the study of ultrasound contrast agents using a commercial imaging system. / Sboros, V.; Moran, C.; Anderson, T.; Gatzoulis, L.; Criton, A.; Averkiou, M.; Pye, S.; McDicken, N.

In: Physics in Medicine and Biology, Vol. 46, No. 12, 2001, p. 3301-3321.

Research output: Contribution to journalArticle

TY - JOUR

T1 - An in vitro system for the study of ultrasound contrast agents using a commercial imaging system

AU - Sboros, V.

AU - Moran, C.

AU - Anderson, T.

AU - Gatzoulis, L.

AU - Criton, A.

AU - Averkiou, M.

AU - Pye, S.

AU - McDicken, N.

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KW - imaging

KW - in vitro system

KW - physics

KW - medicine

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M3 - Article

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JO - Physics in Medicine and Biology

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ER -