An improved optimistic three-stage model for the spread of HIV amongst injecting intravenous drug users

David Greenhalgh, Wafa Al-Fwzan, Saudi-Arabian Government (Funder)

Research output: Contribution to journalArticle

Abstract

We start off this paper with a brief introduction to modeling Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) amongst sharing, injecting drug users (IDUs). Then we describe the mathematical model which we shall use which extends an existing model of the spread of HIV and AIDS amongst IDUs by incorporating loss of HIV infectivity over time. This is followed by the derivation of a key epidemiological parameter, the basic reproduction number R0. Next we give some analytical equilibrium, local and global stability results. We show that if R0 &gte 1 then the disease will always die out. For R0 > 1 there is the disease-free equilibrium (DFE) and a unique endemic equilibrium. The DFE is unstable. An approximation argument shows that we expect the endemic equilibrium to be locally stable. We next discuss a more realistic version of the model, relaxing the assumption that the number of addicts remains constant and obtain some results for this model. The subsequent section gives simulations for both models confirming that if R0 &gte 1 then the disease will die out and if R0 > 1 then if it is initially present the disease will tend to the unique endemic equilibrium. The simulation results are compared with the original model with no loss of HIV infectivity. Next the implications of these results for control strategies are considered. A brief summary concludes the paper.
LanguageEnglish
Pages286-299
Number of pages13
JournalDiscrete and Continuous Dynamical Systems - Series A
Volume2009
DOIs
Publication statusPublished - 2009

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Viruses
Virus
Drugs
Endemic Equilibrium
Die
Basic Reproduction number
Model
Local Stability
Global Stability
Control Strategy
Sharing
Simulation
Unstable
Human
Tend
Mathematical Model
Mathematical models
Approximation
Modeling

Keywords

  • hiv
  • aids
  • infectivity
  • equilibrium analysis
  • stability analysis
  • global stability

Cite this

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abstract = "We start off this paper with a brief introduction to modeling Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) amongst sharing, injecting drug users (IDUs). Then we describe the mathematical model which we shall use which extends an existing model of the spread of HIV and AIDS amongst IDUs by incorporating loss of HIV infectivity over time. This is followed by the derivation of a key epidemiological parameter, the basic reproduction number R0. Next we give some analytical equilibrium, local and global stability results. We show that if R0 &gte 1 then the disease will always die out. For R0 > 1 there is the disease-free equilibrium (DFE) and a unique endemic equilibrium. The DFE is unstable. An approximation argument shows that we expect the endemic equilibrium to be locally stable. We next discuss a more realistic version of the model, relaxing the assumption that the number of addicts remains constant and obtain some results for this model. The subsequent section gives simulations for both models confirming that if R0 &gte 1 then the disease will die out and if R0 > 1 then if it is initially present the disease will tend to the unique endemic equilibrium. The simulation results are compared with the original model with no loss of HIV infectivity. Next the implications of these results for control strategies are considered. A brief summary concludes the paper.",
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An improved optimistic three-stage model for the spread of HIV amongst injecting intravenous drug users. / Greenhalgh, David; Al-Fwzan, Wafa; Saudi-Arabian Government (Funder).

In: Discrete and Continuous Dynamical Systems - Series A, Vol. 2009, 2009, p. 286-299.

Research output: Contribution to journalArticle

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