An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events

Esmaeil Heydari, Duncan Graham, Jonathan M. Cooper, Alasdair W. Clark

Research output: Chapter in Book/Report/Conference proceedingConference contribution book

2 Citations (Scopus)
349 Downloads (Pure)

Abstract

We report a versatile nanophotonic biosensing platform that enables both colorimetric detection and enhanced Raman spectroscopy detection of molecular binding events. Through the integration of electron-beam lithography, dip-pen-nanolithography and molecular self-assembly, we demonstrate plasmonic nanostructures which change geometry and plasmonic properties in response to molecularly-mediated nanoparticle binding events. These biologically-active nanostructured surfaces hold considerable potential for use as multiplexed sensor platforms for point-of-care diagnostics, and as scaffolds for a new generation of molecularly dynamic metamaterials.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
EditorsTuan Vo-Dinh, Joseph R. Lakowicz
Volume9340
DOIs
Publication statusPublished - 11 Mar 2015
EventPlasmonics in Biology and Medicine XII - San Francisco, United States
Duration: 7 Feb 20158 Feb 2015

Conference

ConferencePlasmonics in Biology and Medicine XII
CountryUnited States
CitySan Francisco
Period7/02/158/02/15

Keywords

  • biosensor
  • colorimetric sensing
  • dip-pen nanolithography
  • DNA
  • electron-beam lithography
  • nanoparticles
  • plasmonics
  • SERS

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    Heydari, E., Graham, D., Cooper, J. M., & Clark, A. W. (2015). An engineered nano-plasmonic biosensing surface for colorimetric and SERS detection of DNA-hybridization events. In T. Vo-Dinh, & J. R. Lakowicz (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 9340). [93400O-1] https://doi.org/10.1117/12.2076915