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Abstract
This paper details a simple and efficient 3-component synthesis of 1-substituted 1,2,3-triazoles using a primary amine, 2,2-dimethoxyacetaldehyde and tosylhydrazide. The reaction proceeds in good to excel- lent yields using either aliphatic or aromatic amine substrates and is tolerant of a wide range of functional groups including electron-rich and deficient aryl groups, terminal alkynes, ketones and highly sterically encumbered amines
Original language | English |
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Article number | 152483 |
Journal | Tetrahedron Letters |
Volume | 61 |
Issue number | 45 |
Early online date | 28 Sept 2020 |
DOIs | |
Publication status | Published - 5 Nov 2020 |
Keywords
- 1,2,3-TriazoleDimethoxyacetaldehyde
- Tosyl hydrazide
- heterocyclisation
- azide-free
- acetylene-free
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Dive into the research topics of 'An azide and acetylene free synthesis of 1-substituted 1,2,3-triazoles'. Together they form a unique fingerprint.Projects
- 1 Finished
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Accelerated Discovery and Development of New Medicines: Prosperity Partnership for a Healthier Nation
Kerr, W. (Principal Investigator), Brown, C. (Co-investigator), Florence, A. (Co-investigator), Jamieson, C. (Co-investigator), Johnston, B. (Co-investigator), Murphy, J. (Co-investigator), Palmer, D. (Co-investigator) & Tomkinson, N. (Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/01/19 → 30/09/24
Project: Research