An alternative picture of alkali-metal-mediated metallation: cleave and capture chemistry

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

This perspective article takes an alternative look at alkali-metal-mediated chemistry (exchange of a relatively inert C-H bond for a more reactive C-metal bond by a multicomponent reagent usually containing an alkali metal and a less electropositive metal such as magnesium or zinc). It pictures that the cleavage of selected C-H bonds can be accompanied by the capturing of the generated anion by the multi (Lewis acid)-(Lewis base) character of the residue of the bimetallic base. In this way small atoms or molecules (hydrides, oxygen-based anions) as well as sensitive organic anions (of substituted aromatic compounds, ethers or alkenes) can be captured. Cleave and capture reactions which occur in special positions on the organic substrate are also included.

LanguageEnglish
Pages6676-6693
Number of pages18
JournalDalton Transactions
Volume42
Issue number19
Early online date18 Feb 2013
DOIs
Publication statusPublished - 2013

Fingerprint

Alkali Metals
Anions
Metals
Lewis Bases
Lewis Acids
Ethers
Aromatic compounds
Alkenes
Hydrides
Magnesium
Zinc
Oxygen
Atoms
Molecules
Substrates

Keywords

  • alkali-metal-mediated metallation
  • alkyl
  • magnesium hydride
  • functionalized aromatics
  • aluminium compounds
  • hydrogen storage
  • structural basis
  • ortho-zincation
  • lithium
  • base
  • ethers
  • cleave and capture chemistry

Cite this

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An alternative picture of alkali-metal-mediated metallation : cleave and capture chemistry. / Mulvey, Robert E.

In: Dalton Transactions, Vol. 42, No. 19, 2013, p. 6676-6693.

Research output: Contribution to journalArticle

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