Amphiphilic network as nanoreactor for enzymes in organic solvents

Nico Bruns, Joerg C. Tiller

Research output: Contribution to journalArticlepeer-review

186 Citations (Scopus)


Enzymes are powerful biocatalysts that work naturally in water but are also active in organic solvents. Here, we present a nanophase-separated amphiphilic network, where an enzyme is entrapped into its hydrophilic domains. A substrate that diffuses into the other, hydrophobic, phase of such a network can access the biocatalyst via the extremely large interface. Entrapped horseradish peroxidase and chloroperoxidase showed dramatically increased activity and operational stability compared to the native enzymes.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalNano Letters
Issue number1
Publication statusPublished - 1 Jan 2005


  • organic solvents
  • biocatalysts
  • horseradish peroxidase


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