Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect

Huw J. Davies; Antionio M. Ruda; Nicholas C. O. Tomkinson

doi:10.1016/j.tetlet.2006.12.072

Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect

Huw J. Davies
, Antionio M. Ruda
, Nicholas C. O. Tomkinson

Pure And Applied Chemistry

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.

Original language	Undefined/Unknown
Pages (from-to)	1461-1464
Number of pages	4
Journal	Tetrahedron Letters
Volume	48
Issue number	8
DOIs	https://doi.org/10.1016/j.tetlet.2006.12.072
Publication status	Published - 2007

Keywords

aminocatalysis
Baylis-Hillman reaction
solvent
aldehydes
ketones

Access to Document

10.1016/j.tetlet.2006.12.072

Cite this

@article{84a6bd8360d24e06a88e5da99528aa8f,

title = "Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect",

abstract = "Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.",

keywords = "aminocatalysis , Baylis-Hillman reaction , solvent , aldehydes , ketones",

author = "Davies, \{Huw J.\} and Ruda, \{Antionio M.\} and Tomkinson, \{Nicholas C. O.\}",

year = "2007",

doi = "10.1016/j.tetlet.2006.12.072",

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volume = "48",

pages = "1461--1464",

journal = "Tetrahedron Letters",

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publisher = "Elsevier Limited",

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T1 - Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect

AU - Davies, Huw J.

AU - Ruda, Antionio M.

AU - Tomkinson, Nicholas C. O.

PY - 2007

Y1 - 2007

N2 - Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.

AB - Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.

KW - aminocatalysis

KW - Baylis-Hillman reaction

KW - solvent

KW - aldehydes

KW - ketones

U2 - 10.1016/j.tetlet.2006.12.072

DO - 10.1016/j.tetlet.2006.12.072

M3 - Article

SN - 0040-4039

VL - 48

SP - 1461

EP - 1464

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 8

ER -