Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect

Huw J. Davies, Antionio M. Ruda, Nicholas C. O. Tomkinson

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30 Citations (Scopus)


Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.
Original languageUndefined/Unknown
Pages (from-to)1461-1464
Number of pages4
JournalTetrahedron Letters
Issue number8
Publication statusPublished - 2007


  • aminocatalysis
  • Baylis-Hillman reaction
  • solvent
  • aldehydes
  • ketones

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