Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect

Huw J. Davies, Antionio M. Ruda, Nicholas C. O. Tomkinson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.
LanguageUndefined/Unknown
Pages1461-1464
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number8
DOIs
Publication statusPublished - 2007

Keywords

  • aminocatalysis
  • Baylis-Hillman reaction
  • solvent
  • aldehydes
  • ketones

Cite this

Davies, Huw J. ; Ruda, Antionio M. ; Tomkinson, Nicholas C. O. / Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 8. pp. 1461-1464.
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Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect. / Davies, Huw J.; Ruda, Antionio M.; Tomkinson, Nicholas C. O.

In: Tetrahedron Letters, Vol. 48, No. 8, 2007, p. 1461-1464.

Research output: Contribution to journalArticle

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AU - Ruda, Antionio M.

AU - Tomkinson, Nicholas C. O.

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AB - Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.

KW - aminocatalysis

KW - Baylis-Hillman reaction

KW - solvent

KW - aldehydes

KW - ketones

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DO - 10.1016/j.tetlet.2006.12.072

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JO - Tetrahedron Letters

T2 - Tetrahedron Letters

JF - Tetrahedron Letters

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