Examination of the amino-catalytic Baylis-Hillman reaction in the presence of proline and imidazole has revealed that water plays a crucial role in the acceleration of the reaction, allowing for excellent yields of the adduct between Me vinyl ketone and a variety of aldehydes.
- Baylis-Hillman reaction
Davies, H. J., Ruda, A. M., & Tomkinson, N. C. O. (2007). Aminocatalysis of the Baylis-Hillman reaction. An important solvent effect. Tetrahedron Letters, 48(8), 1461-1464. https://doi.org/10.1016/j.tetlet.2006.12.072