Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence

F. Ducancel, E.G. Rowan, E. Cassar, A.L. Harvey, A. Menez, J.C. Boulain

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We prepared a cDNA library from venom glands of the green mamba Dendroaspis angusticeps. A cDNA clone was isolated using an appropriate nucleotide probe. The nucleotide sequence codes for a 21 residue signal peptide followed by a 65 residue protein having the amino acid sequence of muscarinic toxin 2, as confirmed in the accompanying paper (Karlsson, E., Risinger, C., Jolkkonen, M., Wernstedt, C. and Adem, A.). The cDNA encoding the muscarinic toxin has been compared with those encoding other snake toxins. There are close similarities with short-chain curaremimetic neurotoxins.
Original languageEnglish
Pages (from-to)516-520
Number of pages4
JournalToxicon
Volume29
Issue number4-5
DOIs
Publication statusPublished - 1991

Keywords

  • cDNA nucleotide sequence
  • Dendroaspis angusticeps
  • venom glands
  • muscarinic toxin

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