Amidation of unactivated ester derivatives mediated by trifluoroethanol

Christopher G. McPherson, Nicola Caldwell, Craig Jamieson, Iain Simpson, Allan J. B. Watson

Research output: Contribution to journalArticle

17 Citations (Scopus)
19 Downloads (Pure)

Abstract

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.
Original languageEnglish
Number of pages12
JournalOrganic and Biomolecular Chemistry
DOIs
Publication statusPublished - 4 Apr 2017

Keywords

  • amidation
  • ester derivatives
  • trifluoroethanol
  • chiral integrity
  • catalytic amidation protocol
  • acyclic secondary amines

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