Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

J. Pollock; A. S. Low; R. E. McHugh; A. Muwonge; M. P. Stevens; A. Corbishley; D. L. Gally

doi:10.1016/j.cmi.2020.02.028

Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

J. Pollock, A. S. Low, R. E. McHugh, A. Muwonge, M. P. Stevens, A. Corbishley, D. L. Gally^*

^*Corresponding author for this work

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

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Abstract

Background: This review follows on from the International Conference on One Health Antimicrobial Resistance (ICOHAR 2019), where strategies to improve the fundamental understanding and management of antimicrobial resistance at the interface between humans, animals and the environment were discussed. Objective: This review identifies alternatives to antimicrobials in a One Health context, noting how advances in genomic technologies are assisting their development and enabling more targeted use of antimicrobials. Sources: Key articles on the use of microbiota modulation, livestock breeding and gene editing, vaccination, antivirulence strategies and bacteriophage therapy are discussed. Content: Antimicrobials are central for disease control, but reducing their use is paramount as a result of the rise of transmissible antimicrobial resistance. This review discusses antimicrobial alternatives in the context of improved understanding of fundamental host–pathogen and microbiota interactions using genomic tools. Implications: Host and microbial genomics and other novel technologies play an important role in devising disease control strategies for healthier animals and humans that in turn reduce our reliance on antimicrobials.

Original language	English
Pages (from-to)	1617-1621
Number of pages	5
Journal	Clinical Microbiology and Infection
Volume	26
Issue number	12
Early online date	24 Mar 2020
DOIs	https://doi.org/10.1016/j.cmi.2020.02.028
Publication status	Published - 31 Dec 2020

Funding

DLG and MPS receive core strategic funding to the Roslin Institute from the Biotechnology and Biological Sciences Research Council (BBSRC) ( BBS/E/D/20002172 , BBS/E/D/20002173 , BBS/E/D/20002174 ), which supports JP and AL. MPS is also supported by BBSRC grants BB/N001591/1 , BB/K015524/1 and BB/M028305/1 ; and DLG by BB/P02095X/1 and BB/J004227/1 . AM and JP are supported by a BBSRC Future Leadership Fellowship ( BB/P007767/1 ). AC, DLG and JP are supported by NERC grant NE/N020162/1 . RM is supported the University of Strathclyde and the Medical, Veterinary and Life Sciences Doctoral Training Programme at the University of Glasgow. All authors report no conflicts of interest relevant to this review.

Keywords

antibiotic
antivirulence
bacteriophage
genetics
genomics
microbiome
vaccine

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AU - Stevens, M. P.

AU - Corbishley, A.

AU - Gally, D. L.

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Alternatives to antibiotics in a One Health context and the role genomics can play in reducing antimicrobial use

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