Allylic fluorination via an unusual alkene z/e isomerisation

J.A.B. Laurenson, S. Meiries, J.M. Percy, R. Roig, University of Leicester (Funder), Engineering and Physical Sciences Research Council (EPSRC) (Funder), WestCHEM (Funder)

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


The isomerisation of readily available (Z)-4-(para-methoxybenzyloxy)- 1 -chloro-2-butene was achieved under mild conditions to afford the much less accessible E-diastereoisomer. This was an effective Substrate in Sharpless asymmetric dihydroxylation (AD) reactions, delivering highly enantiomerically enriched fluorinated butene triol building blocks.
Original languageEnglish
Pages (from-to)3571-3573
Number of pages2
JournalTetrahedron Letters
Issue number26
Publication statusPublished - 1 Jul 2009


  • efficient
  • fluoride
  • route


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