Alkene dihydroxylation with malonoyl peroxides: catalysis using fluorinated alcohols

Sylvain Picon, Michael Rawling, Matthew Campbell, Nick Tomkinson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

The effect of fluorinated alcohols on the dihydroxylation of alkenes using cyclopropyl malonoyl peroxide is described. Addition of perfluorotert-butyl alcohol to a toluene solution of alkene and peroxide increases the rate of product formation and the stereoselectivity observed, providing a simple and effective method for acceleration of this important
Original languageEnglish
Pages (from-to)6250-6253
Number of pages4
JournalOrganic Letters
Volume14
Issue number24
DOIs
Publication statusPublished - 21 Dec 2012

Keywords

  • alkene dihydroxylation
  • malonoyl peroxides
  • catalysis
  • fluorinated alcohols

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