Alkali-metal-mediated zincation of polycyclic aromatic hydrocarbons: synthesis and structures of mono- and dizincated naphthalenes

R.E. Mulvey, W. Clegg, E. Hevia, C.T. O'Hara, S.H. Dale, L.M. Hogg, G.W. Honeyman

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Since the pioneering work of Schlenk nearly a century ago, alkali-metal–organic compounds (organolithium reagents, in particular) have served as frontline reagents in the battle to advance chemical synthesis. Metal–hydrogen exchange (metalation) in which a relatively inert carbon–hydrogen bond is transformed into a more labile carbon–alkali-metal bond, thus opening up a myriad of bond-forming possibilities at the carbon center, represents one of the oldest and still most
important general uses of these centurial reagents.[1, 2]
Original languageEnglish
Pages (from-to)6548-6550
Number of pages3
JournalAngewandte Chemie
Volume45
DOIs
Publication statusPublished - 2006

Keywords

  • alkali metals
  • zinc
  • polycyclic aromatic hydrocarbons
  • metalation
  • crystal structures

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