Abstract
Since the pioneering work of Schlenk nearly a century ago, alkali-metal–organic compounds (organolithium reagents, in particular) have served as frontline reagents in the battle to advance chemical synthesis. Metal–hydrogen exchange (metalation) in which a relatively inert carbon–hydrogen bond is transformed into a more labile carbon–alkali-metal bond, thus opening up a myriad of bond-forming possibilities at the carbon center, represents one of the oldest and still most
important general uses of these centurial reagents.[1, 2]
important general uses of these centurial reagents.[1, 2]
Original language | English |
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Pages (from-to) | 6548-6550 |
Number of pages | 3 |
Journal | Angewandte Chemie |
Volume | 45 |
DOIs | |
Publication status | Published - 2006 |
Keywords
- alkali metals
- zinc
- polycyclic aromatic hydrocarbons
- metalation
- crystal structures