Alkali-metal-mediated synergistic effects in polar main group organometallic chemistry

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The development of synthetic chemistry since the early 1900s owes much to the service of organolithium reagents. Brilliant bases (e.g., deprotonating C–H bonds), nucleophiles (e.g., adding to unsaturated molecules), and transfer agents (e.g., delivering ligands to other metals), these versatile virtuosi and to a lesser extent the organic derivatives of the other common alkali metals sodium and potassium have proved indispensable in both academia and technology. Today these monometallic compounds are still utilized widely in synthetic campaigns, but in recent years they have been joined by an assortment of bimetallic formulations that also contain an alkali metal but in company with another metal. These bimetallic formulations often exhibit unique chemistry that can be interpreted in terms of synergistic effects, for which the alkali metal is essential, though it is often the second metal that performs the synthetic transformation. Here, this “alkali-metal-mediated” chemistry is surveyed focusing mainly on bimetallic formulations containing two alkali metals or an alkali metal paired with magnesium, calcium, zinc, aluminum, or gallium. In this International Year of the Periodic Table (IYPT), we ponder whether a Pairiodic Table of Element Pairs will emerge in the future.
LanguageEnglish
Pages8332-8405
Number of pages74
JournalChemical Reviews
Volume119
Issue number14
DOIs
Publication statusPublished - 19 Mar 2019

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Alkali Metals
Organometallics
Metals
Nucleophiles
Gallium
Aluminum
Magnesium
Zinc
Potassium
Sodium
Ligands
Calcium
Derivatives
Molecules
Industry

Keywords

  • organolithium reagents
  • alkali metals
  • bimetallic formulations

Cite this

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title = "Alkali-metal-mediated synergistic effects in polar main group organometallic chemistry",
abstract = "The development of synthetic chemistry since the early 1900s owes much to the service of organolithium reagents. Brilliant bases (e.g., deprotonating C–H bonds), nucleophiles (e.g., adding to unsaturated molecules), and transfer agents (e.g., delivering ligands to other metals), these versatile virtuosi and to a lesser extent the organic derivatives of the other common alkali metals sodium and potassium have proved indispensable in both academia and technology. Today these monometallic compounds are still utilized widely in synthetic campaigns, but in recent years they have been joined by an assortment of bimetallic formulations that also contain an alkali metal but in company with another metal. These bimetallic formulations often exhibit unique chemistry that can be interpreted in terms of synergistic effects, for which the alkali metal is essential, though it is often the second metal that performs the synthetic transformation. Here, this “alkali-metal-mediated” chemistry is surveyed focusing mainly on bimetallic formulations containing two alkali metals or an alkali metal paired with magnesium, calcium, zinc, aluminum, or gallium. In this International Year of the Periodic Table (IYPT), we ponder whether a Pairiodic Table of Element Pairs will emerge in the future.",
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Alkali-metal-mediated synergistic effects in polar main group organometallic chemistry. / Robertson, Stuart D.; Uzelac, Marina; Mulvey, Robert E.

In: Chemical Reviews, Vol. 119, No. 14, 19.03.2019, p. 8332-8405.

Research output: Contribution to journalArticle

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AU - Uzelac, Marina

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