Alcohol poisoning is a main determinant of recent mortality trends in Russia

evidence from a detailed analysis of mortality statistics and autopsies

David Zaridze, Dimitri Maximovitch, Alexander Lazarev, Vladimir Igitov, Alex Boroda, Jillian Boreham, Peter Boyle, Richard Peto, Paolo Boffetta

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Background: The changes in Russian mortality rates during the last two decades are unprecedented in a modern industrialized country. Although these fluctuations have attracted much interest, trends for major groups of causes of death have been analysed while trends in specific causes of death might shed light on the underlying determinants.
Methods: We analysed trends in total and cause-specific mortality in Russia for 1991–2006. The records of 24 836 forensic autopsies carried out during the period 1990–2004 in the city of Barnaul were analysed with respect to blood alcohol level.
Results: Diseases of the circulatory system (in the age group 35–69 years) and external causes (in the age group 15–34 years) were the main contributors to the fluctuations in Russian mortality rates observed in 1991–2006. The largest relative changes were for conditions directly related to alcohol intake. Among cardiovascular diseases, fluctuations were due to ‘other forms’ of acute and chronic ischaemia, and to atherosclerotic heart disease, while rates of myocardial infarction were low and relatively constant. In the autopsy series a very high proportion of decedents whose death was attributed to ‘other’ or ‘not classified’ cardiovascular diseases had lethal or potentially lethal concentrations of ethanol in blood.
Conclusions: The increases in mortality in 1991–94 and in 1998–2003 coincided with economic and societal crisis, while decreases in 1994–98 and 2003–06 correlate with improvement in the economic situation. Excessive alcohol intake is a major cause of premature male Russian mortality, although many alcohol-related deaths are wrongly attributed to diseases of the circulatory system.
Original languageEnglish
Pages (from-to)143-53
Number of pages11
JournalInternational Journal of Epidemiology
Volume38
Issue number1
Early online date4 Sep 2008
DOIs
Publication statusPublished - 2009

Fingerprint

Russia
Poisoning
Autopsy
Alcohols
Mortality
Cardiovascular System
Cause of Death
Cardiovascular Diseases
Age Groups
Economics
Developed Countries
Heart Diseases
Ethanol
Ischemia
Myocardial Infarction

Keywords

  • young adults
  • autopsy
  • mortality rates
  • sex factors
  • morality trends
  • Aged
  • neoplasms
  • adult
  • alcohol-related disorders
  • Cardiovascular Diseases
  • Middle Aged
  • Russia
  • adolescents
  • alcohol poisoning
  • ethanol

Cite this

Zaridze, David ; Maximovitch, Dimitri ; Lazarev, Alexander ; Igitov, Vladimir ; Boroda, Alex ; Boreham, Jillian ; Boyle, Peter ; Peto, Richard ; Boffetta, Paolo. / Alcohol poisoning is a main determinant of recent mortality trends in Russia : evidence from a detailed analysis of mortality statistics and autopsies. In: International Journal of Epidemiology. 2009 ; Vol. 38, No. 1. pp. 143-53.
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abstract = "Background: The changes in Russian mortality rates during the last two decades are unprecedented in a modern industrialized country. Although these fluctuations have attracted much interest, trends for major groups of causes of death have been analysed while trends in specific causes of death might shed light on the underlying determinants.Methods: We analysed trends in total and cause-specific mortality in Russia for 1991–2006. The records of 24 836 forensic autopsies carried out during the period 1990–2004 in the city of Barnaul were analysed with respect to blood alcohol level.Results: Diseases of the circulatory system (in the age group 35–69 years) and external causes (in the age group 15–34 years) were the main contributors to the fluctuations in Russian mortality rates observed in 1991–2006. The largest relative changes were for conditions directly related to alcohol intake. Among cardiovascular diseases, fluctuations were due to ‘other forms’ of acute and chronic ischaemia, and to atherosclerotic heart disease, while rates of myocardial infarction were low and relatively constant. In the autopsy series a very high proportion of decedents whose death was attributed to ‘other’ or ‘not classified’ cardiovascular diseases had lethal or potentially lethal concentrations of ethanol in blood.Conclusions: The increases in mortality in 1991–94 and in 1998–2003 coincided with economic and societal crisis, while decreases in 1994–98 and 2003–06 correlate with improvement in the economic situation. Excessive alcohol intake is a major cause of premature male Russian mortality, although many alcohol-related deaths are wrongly attributed to diseases of the circulatory system.",
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Alcohol poisoning is a main determinant of recent mortality trends in Russia : evidence from a detailed analysis of mortality statistics and autopsies. / Zaridze, David; Maximovitch, Dimitri; Lazarev, Alexander; Igitov, Vladimir; Boroda, Alex; Boreham, Jillian; Boyle, Peter; Peto, Richard; Boffetta, Paolo.

In: International Journal of Epidemiology, Vol. 38, No. 1, 2009, p. 143-53.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alcohol poisoning is a main determinant of recent mortality trends in Russia

T2 - evidence from a detailed analysis of mortality statistics and autopsies

AU - Zaridze, David

AU - Maximovitch, Dimitri

AU - Lazarev, Alexander

AU - Igitov, Vladimir

AU - Boroda, Alex

AU - Boreham, Jillian

AU - Boyle, Peter

AU - Peto, Richard

AU - Boffetta, Paolo

PY - 2009

Y1 - 2009

N2 - Background: The changes in Russian mortality rates during the last two decades are unprecedented in a modern industrialized country. Although these fluctuations have attracted much interest, trends for major groups of causes of death have been analysed while trends in specific causes of death might shed light on the underlying determinants.Methods: We analysed trends in total and cause-specific mortality in Russia for 1991–2006. The records of 24 836 forensic autopsies carried out during the period 1990–2004 in the city of Barnaul were analysed with respect to blood alcohol level.Results: Diseases of the circulatory system (in the age group 35–69 years) and external causes (in the age group 15–34 years) were the main contributors to the fluctuations in Russian mortality rates observed in 1991–2006. The largest relative changes were for conditions directly related to alcohol intake. Among cardiovascular diseases, fluctuations were due to ‘other forms’ of acute and chronic ischaemia, and to atherosclerotic heart disease, while rates of myocardial infarction were low and relatively constant. In the autopsy series a very high proportion of decedents whose death was attributed to ‘other’ or ‘not classified’ cardiovascular diseases had lethal or potentially lethal concentrations of ethanol in blood.Conclusions: The increases in mortality in 1991–94 and in 1998–2003 coincided with economic and societal crisis, while decreases in 1994–98 and 2003–06 correlate with improvement in the economic situation. Excessive alcohol intake is a major cause of premature male Russian mortality, although many alcohol-related deaths are wrongly attributed to diseases of the circulatory system.

AB - Background: The changes in Russian mortality rates during the last two decades are unprecedented in a modern industrialized country. Although these fluctuations have attracted much interest, trends for major groups of causes of death have been analysed while trends in specific causes of death might shed light on the underlying determinants.Methods: We analysed trends in total and cause-specific mortality in Russia for 1991–2006. The records of 24 836 forensic autopsies carried out during the period 1990–2004 in the city of Barnaul were analysed with respect to blood alcohol level.Results: Diseases of the circulatory system (in the age group 35–69 years) and external causes (in the age group 15–34 years) were the main contributors to the fluctuations in Russian mortality rates observed in 1991–2006. The largest relative changes were for conditions directly related to alcohol intake. Among cardiovascular diseases, fluctuations were due to ‘other forms’ of acute and chronic ischaemia, and to atherosclerotic heart disease, while rates of myocardial infarction were low and relatively constant. In the autopsy series a very high proportion of decedents whose death was attributed to ‘other’ or ‘not classified’ cardiovascular diseases had lethal or potentially lethal concentrations of ethanol in blood.Conclusions: The increases in mortality in 1991–94 and in 1998–2003 coincided with economic and societal crisis, while decreases in 1994–98 and 2003–06 correlate with improvement in the economic situation. Excessive alcohol intake is a major cause of premature male Russian mortality, although many alcohol-related deaths are wrongly attributed to diseases of the circulatory system.

KW - young adults

KW - autopsy

KW - mortality rates

KW - sex factors

KW - morality trends

KW - Aged

KW - neoplasms

KW - adult

KW - alcohol-related disorders

KW - Cardiovascular Diseases

KW - Middle Aged

KW - Russia

KW - adolescents

KW - alcohol poisoning

KW - ethanol

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DO - 10.1093/ije/dyn160

M3 - Article

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JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 1

ER -