Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction

Ulrik Wisløff, Jan P Loennechen, Susan Currie, Godfrey L Smith, Øyvind Ellingsen

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

Although it is generally accepted that endurance training improves cardiac function after myocardial infarction the sub-cellular mechanisms are uncertain. The present study reports the effects of aerobic endurance training on myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+ in cardiomyocytes from healthy and failing rat hearts.
Original languageEnglish
Pages (from-to)162-174
Number of pages13
JournalCardiovascular Research
Volume54
Issue number1
DOIs
Publication statusPublished - Apr 2002

Keywords

  • heart failure
  • myocytes
  • hypertrophy

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