Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction

Ulrik Wisløff; Jan P Loennechen; Susan Currie; Godfrey L Smith; Øyvind Ellingsen

doi:10.1016/S0008-6363(01)00565-X

Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction

Ulrik Wisløff, Jan P Loennechen, Susan Currie, Godfrey L Smith, Øyvind Ellingsen

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

189 Citations (Scopus)

Abstract

Although it is generally accepted that endurance training improves cardiac function after myocardial infarction the sub-cellular mechanisms are uncertain. The present study reports the effects of aerobic endurance training on myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+ in cardiomyocytes from healthy and failing rat hearts.

Original language	English
Pages (from-to)	162-174
Number of pages	13
Journal	Cardiovascular Research
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/S0008-6363(01)00565-X
Publication status	Published - Apr 2002

Keywords

heart failure
myocytes
hypertrophy

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10.1016/S0008-6363(01)00565-X

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abstract = "Although it is generally accepted that endurance training improves cardiac function after myocardial infarction the sub-cellular mechanisms are uncertain. The present study reports the effects of aerobic endurance training on myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+ in cardiomyocytes from healthy and failing rat hearts.",

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AU - Smith, Godfrey L

AU - Ellingsen, Øyvind

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AB - Although it is generally accepted that endurance training improves cardiac function after myocardial infarction the sub-cellular mechanisms are uncertain. The present study reports the effects of aerobic endurance training on myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+ in cardiomyocytes from healthy and failing rat hearts.

KW - heart failure

KW - myocytes

KW - hypertrophy

U2 - 10.1016/S0008-6363(01)00565-X

DO - 10.1016/S0008-6363(01)00565-X

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JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 1

ER -

Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction

Abstract

Keywords

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