Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction

Ulrik Wisløff, Jan P Loennechen, Susan Currie, Godfrey L Smith, Øyvind Ellingsen

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Although it is generally accepted that endurance training improves cardiac function after myocardial infarction the sub-cellular mechanisms are uncertain. The present study reports the effects of aerobic endurance training on myocardial mass, myocyte dimensions, contractile function, Ca2+ handling, and myofilament responsiveness to Ca2+ in cardiomyocytes from healthy and failing rat hearts.
LanguageEnglish
Pages162-174
Number of pages13
JournalCardiovascular Research
Volume54
Issue number1
DOIs
Publication statusPublished - Apr 2002

Fingerprint

Myofibrils
Cardiac Myocytes
Muscle Cells
Hypertrophy
Myocardial Infarction
Exercise

Keywords

  • heart failure
  • myocytes
  • hypertrophy

Cite this

Wisløff, Ulrik ; Loennechen, Jan P ; Currie, Susan ; Smith, Godfrey L ; Ellingsen, Øyvind. / Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. In: Cardiovascular Research. 2002 ; Vol. 54, No. 1. pp. 162-174.
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Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction. / Wisløff, Ulrik; Loennechen, Jan P; Currie, Susan; Smith, Godfrey L; Ellingsen, Øyvind.

In: Cardiovascular Research, Vol. 54, No. 1, 04.2002, p. 162-174.

Research output: Contribution to journalArticle

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