Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications

Adedunni Olusanya, Olayinka Ogunleye, Brian Godman, Joseph Fadare, Mustafa Danesi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

AIM: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients.  METHODS: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors.  RESULTS: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects.  CONCLUSION: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.

LanguageEnglish
Pages33-42
Number of pages10
JournalJournal of Comparative Effectiveness Research
Volume6
Issue number1
Early online date12 Dec 2016
DOIs
Publication statusPublished - 1 Jan 2017

Fingerprint

Carbamazepine
Nigeria
Seizures
Psychomotor Agitation
Educational Status
Anticonvulsants
Headache
Cross-Sectional Studies
Quality of Life
Depression

Keywords

  • adverse events
  • carbamazepine
  • epilepsy
  • Nigeria

Cite this

Olusanya, Adedunni ; Ogunleye, Olayinka ; Godman, Brian ; Fadare, Joseph ; Danesi, Mustafa. / Adverse effects of carbamazepine monotherapy among patients in Nigeria : a pilot study and implications. In: Journal of Comparative Effectiveness Research. 2017 ; Vol. 6, No. 1. pp. 33-42.
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Adverse effects of carbamazepine monotherapy among patients in Nigeria : a pilot study and implications. / Olusanya, Adedunni; Ogunleye, Olayinka; Godman, Brian; Fadare, Joseph; Danesi, Mustafa.

In: Journal of Comparative Effectiveness Research, Vol. 6, No. 1, 01.01.2017, p. 33-42.

Research output: Contribution to journalArticle

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AB - AIM: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients.  METHODS: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors.  RESULTS: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects.  CONCLUSION: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.

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