Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications

Adedunni Olusanya; Olayinka Ogunleye; Brian Godman; Joseph Fadare; Mustafa Danesi

doi:10.2217/cer-2016-0057

Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications

Adedunni Olusanya, Olayinka Ogunleye, Brian Godman, Joseph Fadare, Mustafa Danesi

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

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Abstract

AIM: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients. METHODS: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors. RESULTS: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects. CONCLUSION: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.

Original language	English
Pages (from-to)	33-42
Number of pages	10
Journal	Journal of Comparative Effectiveness Research
Volume	6
Issue number	1
Early online date	12 Dec 2016
DOIs	https://doi.org/10.2217/cer-2016-0057
Publication status	Published - 1 Jan 2017

Keywords

adverse events
carbamazepine
epilepsy
Nigeria

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AU - Fadare, Joseph

AU - Danesi, Mustafa

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N2 - AIM: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients. METHODS: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors. RESULTS: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects. CONCLUSION: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.

AB - AIM: Antiepileptic drugs do cause adverse effects, affecting patients' quality of life, adherence and seizures. Consequently, there is a need to study this among Nigerian patients. METHODS: Descriptive cross-sectional study assessing the extent of adverse effects with carbamazepine monotherapy and potential factors. RESULTS: 54 patients (64.3%) reported no adverse effects, while 30 did. The most common adverse effects were memory problems followed by headaches, restlessness, tiredness and depression. Adverse effects were significantly higher in females, with females with low educational levels having significantly higher rates. Dose, co-medications, seizure control and comorbid conditions did not significantly affect adverse effects. CONCLUSION: Perception of adverse effects was common in patients on carbamazepine monotherapy, more common in women than men. Educational status was important in women.

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KW - carbamazepine

KW - epilepsy

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Adverse effects of carbamazepine monotherapy among patients in Nigeria: a pilot study and implications

Abstract

Keywords

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