Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function

Satirah Zainalabidin, Roger M. Wadsworth, Paul Coats

Research output: Contribution to journalArticle

Abstract

Resistance arteries have been implicated as major contributing factor in the sequela of disease conditions such as hypertension and diabetes and as such are a major focus of cardiovascular research. The paracrine influence of the intimal endothelial layer of resistance arteries is well established. Considering the growing body of evidence substantiating a functionally relevant vascular adventitia in this present study we have established a technique which permits determination of the functional influence of the adventitial layer on resistance artery tone. Isolating adventitial-dependent function, analogous to isolating endothelial function, has potentially significant implication for studying the as yet unexplored role of the microvascular adventitial layer in modulating acute vascular contractile function.
LanguageEnglish
Pages71-77
Number of pages7
JournalAnalytical Biochemistry
Volume499
Early online date25 Jan 2016
DOIs
Publication statusPublished - 15 Apr 2016

Fingerprint

Ablation Techniques
Adventitia
Ablation
Arteries
Blood Vessels
Tunica Intima
Medical problems
Hypertension
Research

Keywords

  • microcirculation
  • adventitia
  • vasoconstriction
  • vasorelaxation
  • pressure autoregulation

Cite this

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title = "Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function",
abstract = "Resistance arteries have been implicated as major contributing factor in the sequela of disease conditions such as hypertension and diabetes and as such are a major focus of cardiovascular research. The paracrine influence of the intimal endothelial layer of resistance arteries is well established. Considering the growing body of evidence substantiating a functionally relevant vascular adventitia in this present study we have established a technique which permits determination of the functional influence of the adventitial layer on resistance artery tone. Isolating adventitial-dependent function, analogous to isolating endothelial function, has potentially significant implication for studying the as yet unexplored role of the microvascular adventitial layer in modulating acute vascular contractile function.",
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Adventitial ablation technique that permits the assessment of adventitial-dependent contribution to microvascular contractile function. / Zainalabidin, Satirah; Wadsworth, Roger M.; Coats, Paul.

In: Analytical Biochemistry, Vol. 499, 15.04.2016, p. 71-77.

Research output: Contribution to journalArticle

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KW - microcirculation

KW - adventitia

KW - vasoconstriction

KW - vasorelaxation

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