Advances in the cobalt-catalysed Pauson-Khand reaction: development of a sulfide-promoted, microwave-assisted protocol

Alison R. Cochrane; William J. Kerr; Laura C. Paterson; Colin M. Pearson; Paul Shaw

doi:10.1016/j.tet.2020.131805

Advances in the cobalt-catalysed Pauson-Khand reaction: development of a sulfide-promoted, microwave-assisted protocol

Alison R. Cochrane, William J. Kerr, Laura C. Paterson, Colin M. Pearson, Paul Shaw

Pure And Applied Chemistry

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Abstract

The development of a sulfide-promoted, microwave-assisted Pauson-Khand reaction has enabled the formation of fused cyclopentenones using sub-stoichiometric quantities of a cobalt mediator over rapid reaction times and with no requirement for an external source of toxic carbon monoxide gas. This protocol displays applicability to both intra- and intermolecular Pauson-Khand reaction examples.

Original language	English
Article number	131805
Number of pages	5
Journal	Tetrahedron
Volume	78
Early online date	17 Dec 2020
DOIs	https://doi.org/10.1016/j.tet.2020.131805
Publication status	Published - 8 Jan 2021

Keywords

catalysis
cobalt
Pauson-Khand

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10.1016/j.tet.2020.131805

Cochrane-etal-Tetrahedron-2020-Advances-in-the-cobalt-catalysed-Pauson-Khand-reactionAccepted author manuscript, 1.43 MBLicence: CC BY-NC-ND 4.0

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title = "Advances in the cobalt-catalysed Pauson-Khand reaction: development of a sulfide-promoted, microwave-assisted protocol",

abstract = "The development of a sulfide-promoted, microwave-assisted Pauson-Khand reaction has enabled the formation of fused cyclopentenones using sub-stoichiometric quantities of a cobalt mediator over rapid reaction times and with no requirement for an external source of toxic carbon monoxide gas. This protocol displays applicability to both intra- and intermolecular Pauson-Khand reaction examples.",

keywords = "catalysis, cobalt, Pauson-Khand",

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AU - Cochrane, Alison R.

AU - Kerr, William J.

AU - Paterson, Laura C.

AU - Pearson, Colin M.

AU - Shaw, Paul

PY - 2021/1/8

Y1 - 2021/1/8

N2 - The development of a sulfide-promoted, microwave-assisted Pauson-Khand reaction has enabled the formation of fused cyclopentenones using sub-stoichiometric quantities of a cobalt mediator over rapid reaction times and with no requirement for an external source of toxic carbon monoxide gas. This protocol displays applicability to both intra- and intermolecular Pauson-Khand reaction examples.

AB - The development of a sulfide-promoted, microwave-assisted Pauson-Khand reaction has enabled the formation of fused cyclopentenones using sub-stoichiometric quantities of a cobalt mediator over rapid reaction times and with no requirement for an external source of toxic carbon monoxide gas. This protocol displays applicability to both intra- and intermolecular Pauson-Khand reaction examples.

KW - catalysis

KW - cobalt

KW - Pauson-Khand

UR - https://www.sciencedirect.com/journal/tetrahedron

U2 - 10.1016/j.tet.2020.131805

DO - 10.1016/j.tet.2020.131805

M3 - Article

SN - 0040-4020

VL - 78

JO - Tetrahedron

JF - Tetrahedron

M1 - 131805

ER -

Advances in the cobalt-catalysed Pauson-Khand reaction: development of a sulfide-promoted, microwave-assisted protocol

Abstract

Keywords

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