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Abstract
The actinomycetes are Gram-positive bacteria belonging to the order Actinomycetales within the phylum Actinobacteria. They include members with significant economic and medical importance, for example filamentous actinomycetes such as Streptomyces species, which have a propensity to produce a plethora of bioactive secondary metabolites and form symbioses with higher organisms, such as plants and insects. Studying these bacteria is challenging, but also fascinating and very rewarding. As a Microbiology Society initiative, members of the actinomycete research community have been developing a Wikipedia-style resource, called ActinoBase, the purpose of which is to aid in the study of these filamentous bacteria. This review will highlight 10 publications from 2019 that have been of special interest to the ActinoBase community, covering 4 major components of actinomycete research: (i) development and regulation; (ii) specialized metabolites; (iii) ecology and host interactions; and (iv) technology and methodology.
| Original language | English |
|---|---|
| Pages (from-to) | 683-694 |
| Number of pages | 12 |
| Journal | Microbiology (United Kingdom) |
| Volume | 166 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 19 Jun 2020 |
Funding
This work was supported by Norwich Research Park BBSRC Postdoctoral Training Program Studentships BB/M011216/1 (T. C. M. and A. H. R.), an Edge Hill University’s GTA/PhD studentship (L. P. E.), a Natural Environment Research Council (NERC) Doctoral Training Programme grant NE/L002582/1 (S. M. M. P.), an Engineering and Physical Sciences Research Council (EPSRC) Doctoral Training Partnership (E. A.) and University of Strathclyde Research Excellence Award (REA) Studentships (L. C. E. and D. R. M.). This work was supported by Norwich Research Park BBSRC Postdoctoral Training Program Studentships BB/M011216/1 (T. C. M. and A. H. R.), an Edge Hill University?s GTA/PhD studentship (L. P. E.), a Natural Environment Research Council (NERC) Doctoral Training Programme grant NE/L002582/1 (S. M. M. P.), an Engineering and Physical Sciences Research Council (EPSRC) Doctoral Training Partnership (E. A.) and University of Strathclyde Research Excellence Award (REA) Studentships (L. C. E. and D. R. M.). We thank colleagues past and present for useful discussions and the University of East Anglia, Edge Hill University, the University of Strathclyde and the John Innes Centre for providing facilities for research. We thank Matthew I. Hutchings and Geertje Van Keulen for their useful comments on the manuscript. We also thank the Microbiology Society, and Gavin Thomas in particular, for their continuing support of ActinoBase. Finally, we would like to thank all of the ActinoBase community contributors who have dedicated their time and knowledge to building ActinoBase: an actinomycete community wiki.
Keywords
- actinobacteria
- ActinoBase
- antibiotics
- development
- methodology
- microbial ecology
- regulation
- specialized metabolites
- streptomyces
- symbiosis
Fingerprint
Dive into the research topics of 'Advances in actinomycete research: an actinobase review of 2019'. Together they form a unique fingerprint.Projects
- 1 Finished
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Doctoral Training Partnership (DTP 2016-2017 University of Strathclyde) | Addington, Emily
Hoskisson, P. (Principal Investigator), Duncan, K. (Co-investigator) & Addington, E. (Research Co-investigator)
EPSRC (Engineering and Physical Sciences Research Council)
1/01/18 → 4/02/22
Project: Research Studentship - Internally Allocated