Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

K.A. Kane, G. Michael, S.J. Coker

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13 Citations (Scopus)

Abstract

Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.
Original languageEnglish
Pages (from-to)1414-1426
Number of pages12
JournalBritish Journal of Pharmacology
Volume154
Issue number7
DOIs
Publication statusPublished - Aug 2008

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Keywords

  • E-4031
  • guinea pig
  • HMR1556
  • IKr
  • IKs
  • K+ channel blockers
  • proarrhythmia
  • repolarization reserve
  • torsade de pointes

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