Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

K.A. Kane; G. Michael; S.J. Coker

doi:10.1038/bjp.2008.169

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

K.A. Kane, G. Michael, S.J. Coker

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.

Original language	English
Pages (from-to)	1414-1426
Number of pages	12
Journal	British Journal of Pharmacology
Volume	154
Issue number	7
DOIs	https://doi.org/10.1038/bjp.2008.169
Publication status	Published - Aug 2008

Keywords

E-4031
guinea pig
HMR1556
IKr
IKs
K+ channel blockers
proarrhythmia
repolarization reserve
torsade de pointes

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10.1038/bjp.2008.169

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abstract = "Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.",

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AU - Coker, S.J.

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AB - Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.

KW - E-4031

KW - guinea pig

KW - HMR1556

KW - IKr

KW - IKs

KW - K+ channel blockers

KW - proarrhythmia

KW - repolarization reserve

KW - torsade de pointes

UR - http://dx.doi.org/10.1038/bjp.2008.169

U2 - 10.1038/bjp.2008.169

DO - 10.1038/bjp.2008.169

M3 - Article

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EP - 1426

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 7

ER -

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

Abstract

Keywords

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