Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.
- guinea pig
- K+ channel blockers
- repolarization reserve
- torsade de pointes
Kane, K. A., Michael, G., & Coker, S. J. (2008). Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. British Journal of Pharmacology, 154(7), 1414-1426. https://doi.org/10.1038/bjp.2008.169