Administration of a long-acting antipsychotic injection to a child while managing contraindicated polypharmacy interactions and transition between services

Gazala Akram, Fiona Mitchell

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Second-generation antipsychotics are used to treat a variety of psychiatric symptoms and illnesses as well as the behavioural aspects of various neurodevelopmental disorders. However, there is reluctance in using second-generation long-acting injectable antipsychotics in child psychiatry services. We present a case of a 12-year-old child whose presentation and medication regime warranted the use of aripiprazole long-acting injection against a backdrop of potential CYP P450 enzyme interactions as a consequence of polypharmacy. The case also describes the difficulties encountered working across different health sectors and agencies and highlights the ongoing need for skills-based Continuous Professional Development for Child and Adolescent Mental Health Services-based nursing staff.

Original languageEnglish
Article numbere228509
JournalBMJ Case Reports
Issue number6
Publication statusPublished - 14 Jun 2019


  • antipsychotics drugs
  • child psychiatry
  • polypharmacy

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