Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth, David E Minnikin, Else Marie Agger, Peter Andersen, Vincent W Bramwell, Yvonne Perrie, Gurdyal S Besra

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

LanguageEnglish
Pages2029-2032
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number7
DOIs
Publication statusPublished - 1 Apr 2009

Fingerprint

Glycerol
Trehalose
Interleukin-6
Spleen
ammonium bromide

Keywords

  • adjuvants, immunologic
  • vaccination
  • glycerol
  • interferon-gamma
  • interleukin-6

Cite this

Bhowruth, V., Minnikin, D. E., Agger, E. M., Andersen, P., Bramwell, V. W., Perrie, Y., & Besra, G. S. (2009). Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. Bioorganic and Medicinal Chemistry Letters, 19(7), 2029-2032. https://doi.org/10.1016/j.bmcl.2009.02.027
Bhowruth, Veemal ; Minnikin, David E ; Agger, Else Marie ; Andersen, Peter ; Bramwell, Vincent W ; Perrie, Yvonne ; Besra, Gurdyal S. / Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 7. pp. 2029-2032.
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Bhowruth, V, Minnikin, DE, Agger, EM, Andersen, P, Bramwell, VW, Perrie, Y & Besra, GS 2009, 'Adjuvant properties of a simplified C32 monomycolyl glycerol analogue' Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 7, pp. 2029-2032. https://doi.org/10.1016/j.bmcl.2009.02.027

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue. / Bhowruth, Veemal; Minnikin, David E; Agger, Else Marie; Andersen, Peter; Bramwell, Vincent W; Perrie, Yvonne; Besra, Gurdyal S.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 7, 01.04.2009, p. 2029-2032.

Research output: Contribution to journalArticle

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AU - Bhowruth, Veemal

AU - Minnikin, David E

AU - Agger, Else Marie

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AU - Perrie, Yvonne

AU - Besra, Gurdyal S

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KW - adjuvants, immunologic

KW - vaccination

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KW - interferon-gamma

KW - interleukin-6

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