Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth; David E Minnikin; Else Marie Agger; Peter Andersen; Vincent W Bramwell; Yvonne Perrie; Gurdyal S Besra

doi:10.1016/j.bmcl.2009.02.027

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth, David E Minnikin, Else Marie Agger, Peter Andersen, Vincent W Bramwell, Yvonne Perrie, Gurdyal S Besra

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

Original language	English
Pages (from-to)	2029-2032
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/j.bmcl.2009.02.027
Publication status	Published - 1 Apr 2009

Keywords

adjuvants, immunologic
vaccination
glycerol
interferon-gamma
interleukin-6

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2009.02.027

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abstract = "A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).",

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author = "Veemal Bhowruth and Minnikin, {David E} and Agger, {Else Marie} and Peter Andersen and Bramwell, {Vincent W} and Yvonne Perrie and Besra, {Gurdyal S}",

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doi = "10.1016/j.bmcl.2009.02.027",

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T1 - Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

AU - Bhowruth, Veemal

AU - Minnikin, David E

AU - Agger, Else Marie

AU - Andersen, Peter

AU - Bramwell, Vincent W

AU - Perrie, Yvonne

AU - Besra, Gurdyal S

PY - 2009/4/1

Y1 - 2009/4/1

N2 - A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

AB - A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

KW - adjuvants, immunologic

KW - vaccination

KW - glycerol

KW - interferon-gamma

KW - interleukin-6

UR - http://www.sciencedirect.com/science/article/pii/S0960894X09001711

U2 - 10.1016/j.bmcl.2009.02.027

DO - 10.1016/j.bmcl.2009.02.027

M3 - Article

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SN - 0960-894X

VL - 19

SP - 2029

EP - 2032

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Abstract

Keywords

UN SDGs

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