Adjuvant properties of a simplified C32 monomycolyl glycerol analogue

Veemal Bhowruth, David E Minnikin, Else Marie Agger, Peter Andersen, Vincent W Bramwell, Yvonne Perrie, Gurdyal S Besra

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).

Original languageEnglish
Pages (from-to)2029-2032
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number7
DOIs
Publication statusPublished - 1 Apr 2009

Keywords

  • adjuvants, immunologic
  • vaccination
  • glycerol
  • interferon-gamma
  • interleukin-6

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