Projects per year
Abstract
Continuous synthesis and formulation are becoming established in the pharmaceutical industry, however connecting the two through continuous particle formation and isolation still poses significant challenges. This presentation focuses on continuous filtration, washing and drying. Darcy’s law and subsequent modifications describe the rate of filtration; however, there is no equivalent which addresses the removal of closely related impurities of synthesis by filtration and washing, especially when the product exhibits solubility.
API solubility also poses challenges during drying. Presuming the upstream crystallization has delivered particles of the desired size and they are largely unaffected by filtration and washing then drying process has the potential to break fragile particles and to granulate all particles through the formation of crystal-crystal bridges.
In order to develop a successful continuous system for API filtration, washing and drying all of these problems must be overcome.
API solubility also poses challenges during drying. Presuming the upstream crystallization has delivered particles of the desired size and they are largely unaffected by filtration and washing then drying process has the potential to break fragile particles and to granulate all particles through the formation of crystal-crystal bridges.
In order to develop a successful continuous system for API filtration, washing and drying all of these problems must be overcome.
| Original language | English |
|---|---|
| Publication status | Published - 23 Feb 2017 |
| Event | Continuous manufacturing 2017: Adopting Continuous Manufacturing: Defining the Platform for Success - Druids Glen Hotel, Dublin, Ireland Duration: 22 Feb 2017 → 23 Feb 2017 http://www.cvent.com/events/adoption-of-continuous-manufacturing-in-the-pharmaceutical-industry-workshop/event-summary-990c086634c144269689a6550c454c27.aspx |
Workshop
| Workshop | Continuous manufacturing 2017 |
|---|---|
| Abbreviated title | CM2017 |
| Country/Territory | Ireland |
| City | Dublin |
| Period | 22/02/17 → 23/02/17 |
| Internet address |
Keywords
- continuous isolation
- filtration
- wahsing
- drying
- purification
- pharmaceutical
Fingerprint
Dive into the research topics of 'Addressing the challenges of continuous filtration, washing and drying'. Together they form a unique fingerprint.Projects
- 2 Finished
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Doctoral Training Centre In Continuous Manufacturing And Crystallisation | Ottoboni, Sara
Price, C. J., Nordon, A. & Ottoboni, S.
EPSRC (Engineering and Physical Sciences Research Council)
1/10/14 → 12/12/18
Project: Research Studentship - Internally Allocated
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Development of a novel continuous filtration unit for pharmaceutical process development and manufacturing: a case study using paracetamol
Ottoboni, S., Price, C. J., Steven, C., Meehan, E., Barton, A. & Mitchell, A., 13 Oct 2016. 18 p.Research output: Contribution to conference › Proceeding
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Developing pharmaceutical continuous crystallization processes
Price, C. J., 2012.Research output: Contribution to conference › Paper