Abstract
We provide a brief review of the development and application of the Mesolens and its impact on microbiology. Microbial specimens such as infected tissue samples, colonies surfaces, and biofilms are routinely collected at the mesoscale. This means that they are relatively large multi-millimetre-sized samples which contain microscopic detail that must be observed to answer important questions across various sectors. The Mesolens presents the ideal imaging method to study these specimens as no other optical microscope can thanks to its unique combination of low magnification and high numerical aperture providing large field-of-view, high-resolution imaging. We demonstrate the current applications of the Mesolens to microbial imaging and go on to outline the huge potential of the Mesolens to impact other key areas of microbiology.
| Original language | English |
|---|---|
| Pages (from-to) | 139-144 |
| Number of pages | 6 |
| Journal | Journal of Microscopy |
| Volume | 296 |
| Issue number | 2 |
| Early online date | 24 Jan 2023 |
| DOIs | |
| Publication status | E-pub ahead of print - 24 Jan 2023 |
Funding
LMR was funded by the University of Strathclyde and the Leverhulme Trust. BB was funded by the University of Strathclyde. KB was funded by a Medical Research Council‐sponsored Daphne Jackson Trust Fellowship and a Tenovus Small Pilot Grant, S21‐14. WBA was funded by a Leverhulme Trust Emeritus Fellowship. PAH was funded by the Royal Academy of Engineering, RCSRF2021\11\15. GM was funded by The Medical Research Council, MR/K015583/1, and the Biotechnology and Biological Sciences Research Council, BB/P02565X/1 and BB/T011602/1.
Keywords
- biofilm
- high-content imaging
- mesoscopic imaging
- microbiology
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