Activity of pyocin S2 against Pseudomonas aeruginosa biofilms

Karen Smith; Laura Martin; Angela Rinaldi; Ranjith Rajendran; Gordon Ramage; Daniel Walker

doi:10.1128/AAC.05714-11

Activity of pyocin S2 against Pseudomonas aeruginosa biofilms

Karen Smith, Laura Martin, Angela Rinaldi, Ranjith Rajendran, Gordon Ramage, Daniel Walker

Strathclyde Institute Of Pharmacy And Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

In cystic fibrosis patients, chronic lung infection with Pseudomonas aeruginosa and the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity against P. aeruginosa biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of P. aeruginosa infection, we also show that pyocin S2 is highly active in vivo.

Original language	English
Pages (from-to)	1599-1601
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	3
DOIs	https://doi.org/10.1128/AAC.05714-11
Publication status	Published - 14 Feb 2012

Keywords

anti-bacterial agents
biofilms
cystic fibrosis

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10.1128/AAC.05714-11

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title = "Activity of pyocin S2 against Pseudomonas aeruginosa biofilms",

abstract = "In cystic fibrosis patients, chronic lung infection with Pseudomonas aeruginosa and the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity against P. aeruginosa biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of P. aeruginosa infection, we also show that pyocin S2 is highly active in vivo.",

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AU - Rajendran, Ranjith

AU - Ramage, Gordon

AU - Walker, Daniel

PY - 2012/2/14

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N2 - In cystic fibrosis patients, chronic lung infection with Pseudomonas aeruginosa and the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity against P. aeruginosa biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of P. aeruginosa infection, we also show that pyocin S2 is highly active in vivo.

AB - In cystic fibrosis patients, chronic lung infection with Pseudomonas aeruginosa and the associated decline in lung function are the major cause of mortality. In this report, we show that pyocin S2 displays potent activity against P. aeruginosa biofilms, thus representing a potentially improved therapeutic option. Using an invertebrate model of P. aeruginosa infection, we also show that pyocin S2 is highly active in vivo.

KW - anti-bacterial agents

KW - biofilms

KW - cystic fibrosis

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DO - 10.1128/AAC.05714-11

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JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

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Activity of pyocin S2 against Pseudomonas aeruginosa biofilms

Abstract

Keywords

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