Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy

A. G. McCluskey, R. J. Mairs, T. Robson, D. G. Hirst, M. Boyd

Research output: Contribution to journalConference Contribution

Abstract

Radiotherapy given in combination with gene transfer is a promising approach for the treatment of cancer. However, progress in this field depends upon achieving the selective
expression of therapeutic transgenes in tumours. Therefore, radiation-inducible gene promoters have attracted interest because they may enable temporal and spatial gene activation.
LanguageEnglish
Article number82
Pages131-131
Number of pages1
JournalMutagenesis
Volume27
Issue number1
DOIs
Publication statusPublished - 2012
Event34th Annual Meeting of the United Kingdom Environmental Mutagen Society - Nottingham, United Kingdom
Duration: 29 Jun 20111 Jul 2011

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Norepinephrine Plasma Membrane Transport Proteins
3-Iodobenzylguanidine
Radiotherapy
Carcinogens
Genes
Chemical activation
Cells
Radiation
Gene transfer
Transgenes
Transcriptional Activation
Tumors
Neoplasms
Therapeutics

Keywords

  • noradrenaline transporter
  • radiotherapy

Cite this

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title = "Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy",
abstract = "Radiotherapy given in combination with gene transfer is a promising approach for the treatment of cancer. However, progress in this field depends upon achieving the selective expression of therapeutic transgenes in tumours. Therefore, radiation-inducible gene promoters have attracted interest because they may enable temporal and spatial gene activation.",
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Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy. / McCluskey, A. G.; Mairs, R. J.; Robson, T.; Hirst, D. G.; Boyd, M.

In: Mutagenesis, Vol. 27, No. 1, 82, 2012, p. 131-131.

Research output: Contribution to journalConference Contribution

TY - JOUR

T1 - Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy

AU - McCluskey, A. G.

AU - Mairs, R. J.

AU - Robson, T.

AU - Hirst, D. G.

AU - Boyd, M.

PY - 2012

Y1 - 2012

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AB - Radiotherapy given in combination with gene transfer is a promising approach for the treatment of cancer. However, progress in this field depends upon achieving the selective expression of therapeutic transgenes in tumours. Therefore, radiation-inducible gene promoters have attracted interest because they may enable temporal and spatial gene activation.

KW - noradrenaline transporter

KW - radiotherapy

U2 - 10.1093/mutage/ger068

DO - 10.1093/mutage/ger068

M3 - Conference Contribution

VL - 27

SP - 131

EP - 131

JO - Mutagenesis

T2 - Mutagenesis

JF - Mutagenesis

SN - 0267-8357

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ER -