Activation of the noradrenaline transporter gene using the radiation-inducible WAF1-1 promoter sensitizes tumour cells to [I-131] MIBG targeted radiotherapy

A. G. McCluskey, R. J. Mairs, T. Robson, D. G. Hirst, M. Boyd

Research output: Contribution to journalConference Contribution

Abstract

Radiotherapy given in combination with gene transfer is a promising approach for the treatment of cancer. However, progress in this field depends upon achieving the selective
expression of therapeutic transgenes in tumours. Therefore, radiation-inducible gene promoters have attracted interest because they may enable temporal and spatial gene activation.
Original languageEnglish
Article number82
Pages (from-to)131-131
Number of pages1
JournalMutagenesis
Volume27
Issue number1
DOIs
Publication statusPublished - 2012
Event34th Annual Meeting of the United Kingdom Environmental Mutagen Society - Nottingham, United Kingdom
Duration: 29 Jun 20111 Jul 2011

Keywords

  • noradrenaline transporter
  • radiotherapy

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