TY - JOUR
T1 - Activation-deactivation of inter-peptide bond in fluoro-N-(2-hydroxy-5-methyl phenyl)benzamide isomers, induced by the position of the halogen atom in the benzene ring
AU - Moreno-Fuquen, Rodolfo
AU - Mariño-Ocampo, Nory
AU - Tenorio, Juan Carlos
AU - Ellena, Javier
AU - Kennedy, Alan R.
PY - 2022/7/29
Y1 - 2022/7/29
N2 - The synthesis and XRD characterization at 295 K of three isomers, X-fluoro-N-(2-hydroxy5-methyl phenyl) benzamide: (o-FPhB), (m-FPhB), and (p-FPhB), are presented. o-FPhB and m-FPhB show high structural affinity concerning molecular and packing structures. The planarity of the C1-C7(O1)-N1-C8 peptide bond in o-FPhB, and m-FPhB confers high stability, favoring its tendency to acquire a resonant structure in the peptide segment and in the molecule. For p-FPhB, a stereochemical gate opens, leading to the activation of N-H····O interpeptide bonds, defining its supramolecular properties. Active participation of the halogen in the assembly of the structures is observed, forming intramolecular rings and molecule chains during crystal growth. The o-FPhB and m-FPhB form parallel sheets that develop hydrogen C-H···Cg, halogen C-F···Cg, or C=O···Cg interactions. Theoretical evaluations of the properties performed by the DFT/B3LYP/(6-311G(d,p) showed good agreement with the experimental values. The IR analysis reaffirms the presence of N-H, C=O, O-H, C-F, and C-H. In the UV-Vis, an increase in the energetic stability, O···H interactions, and electrostatic potential in the NH region reaffirm the disposition of p-FPhB for the formation of the N-H···O interpeptide bond. A molecular docking on the benzamides involving protein receptors showed similar behavior for all three isomers.
AB - The synthesis and XRD characterization at 295 K of three isomers, X-fluoro-N-(2-hydroxy5-methyl phenyl) benzamide: (o-FPhB), (m-FPhB), and (p-FPhB), are presented. o-FPhB and m-FPhB show high structural affinity concerning molecular and packing structures. The planarity of the C1-C7(O1)-N1-C8 peptide bond in o-FPhB, and m-FPhB confers high stability, favoring its tendency to acquire a resonant structure in the peptide segment and in the molecule. For p-FPhB, a stereochemical gate opens, leading to the activation of N-H····O interpeptide bonds, defining its supramolecular properties. Active participation of the halogen in the assembly of the structures is observed, forming intramolecular rings and molecule chains during crystal growth. The o-FPhB and m-FPhB form parallel sheets that develop hydrogen C-H···Cg, halogen C-F···Cg, or C=O···Cg interactions. Theoretical evaluations of the properties performed by the DFT/B3LYP/(6-311G(d,p) showed good agreement with the experimental values. The IR analysis reaffirms the presence of N-H, C=O, O-H, C-F, and C-H. In the UV-Vis, an increase in the energetic stability, O···H interactions, and electrostatic potential in the NH region reaffirm the disposition of p-FPhB for the formation of the N-H···O interpeptide bond. A molecular docking on the benzamides involving protein receptors showed similar behavior for all three isomers.
KW - crystal structure
KW - fluorobenzamide
KW - Hirshfield surface
KW - MEP
KW - molecular docking
UR - https://www.mdpi.com/journal/molbank/sections/structure_determination_molbank
U2 - 10.3390/M1416
DO - 10.3390/M1416
M3 - Article
SN - 1422-8599
VL - 2022
JO - Molbank
JF - Molbank
IS - 3
M1 - M1416
ER -