Abstract
The effects of the newly synthesized neuromuscular blocking agent, chandonium iodide (17a‐methyl‐3β‐pyrrolidino‐17a‐aza‐D‐homo‐5‐androstene dimethiodide) have been investigated on guinea‐pig isolated ileum and vas deferens preparations. On the ileum, chandonium (0·1–10·0 μg ml−1; 1·6 × 10−7m–1·;6 × 10−5m) had weak muscarinic receptor blocking action (pA2 is 5·7), but no antihistamine properties at the concentration tested. No evidence for anticholinesterase actions was found. On the vas deferens, chandonium (10·50 μg ml−1; 1·6–8·1 × 10−6 m) potentiated responses to exogenous noradrenaline; responses to electrical stimulation were potentiated only in the presence of 50 μg ml−1 chandonium. No adrenoceptor or adrenergic neuron blockade was found. The results provide evidence that chandonium acts selectively at acetylcholine receptors and that it is more active as a nicotinic receptor antagonist than as a muscarinic receptor antagonist.
| Original language | English |
|---|---|
| Pages (from-to) | 617-619 |
| Number of pages | 3 |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 28 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 1 Jan 1976 |
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Keywords
- acetylcholine
- carbachol
- cholinergic receptor
- histamine
- muscle relaxant agent
- noradrenalin
- chandonium iodide
- dose response
- drug response
- ileum
- in vitro study
- smooth muscle contraction
- smooth muscle relaxation
- theoretical study
Cite this
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Actions of the muscle relaxant chandonium iodide on guinea‐pig ileum and vas deferens preparations. / Harvey, A. L.; Paul, Dharam; Rodger, I. W.; Singh, Harkishan.
In: Journal of Pharmacy and Pharmacology, Vol. 28, No. 8, 01.01.1976, p. 617-619.Research output: Contribution to journal › Article
TY - JOUR
T1 - Actions of the muscle relaxant chandonium iodide on guinea‐pig ileum and vas deferens preparations
AU - Harvey, A. L.
AU - Paul, Dharam
AU - Rodger, I. W.
AU - Singh, Harkishan
PY - 1976/1/1
Y1 - 1976/1/1
N2 - The effects of the newly synthesized neuromuscular blocking agent, chandonium iodide (17a‐methyl‐3β‐pyrrolidino‐17a‐aza‐D‐homo‐5‐androstene dimethiodide) have been investigated on guinea‐pig isolated ileum and vas deferens preparations. On the ileum, chandonium (0·1–10·0 μg ml−1; 1·6 × 10−7m–1·;6 × 10−5m) had weak muscarinic receptor blocking action (pA2 is 5·7), but no antihistamine properties at the concentration tested. No evidence for anticholinesterase actions was found. On the vas deferens, chandonium (10·50 μg ml−1; 1·6–8·1 × 10−6 m) potentiated responses to exogenous noradrenaline; responses to electrical stimulation were potentiated only in the presence of 50 μg ml−1 chandonium. No adrenoceptor or adrenergic neuron blockade was found. The results provide evidence that chandonium acts selectively at acetylcholine receptors and that it is more active as a nicotinic receptor antagonist than as a muscarinic receptor antagonist.
AB - The effects of the newly synthesized neuromuscular blocking agent, chandonium iodide (17a‐methyl‐3β‐pyrrolidino‐17a‐aza‐D‐homo‐5‐androstene dimethiodide) have been investigated on guinea‐pig isolated ileum and vas deferens preparations. On the ileum, chandonium (0·1–10·0 μg ml−1; 1·6 × 10−7m–1·;6 × 10−5m) had weak muscarinic receptor blocking action (pA2 is 5·7), but no antihistamine properties at the concentration tested. No evidence for anticholinesterase actions was found. On the vas deferens, chandonium (10·50 μg ml−1; 1·6–8·1 × 10−6 m) potentiated responses to exogenous noradrenaline; responses to electrical stimulation were potentiated only in the presence of 50 μg ml−1 chandonium. No adrenoceptor or adrenergic neuron blockade was found. The results provide evidence that chandonium acts selectively at acetylcholine receptors and that it is more active as a nicotinic receptor antagonist than as a muscarinic receptor antagonist.
KW - acetylcholine
KW - carbachol
KW - cholinergic receptor
KW - histamine
KW - muscle relaxant agent
KW - noradrenalin
KW - chandonium iodide
KW - dose response
KW - drug response
KW - ileum
KW - in vitro study
KW - smooth muscle contraction
KW - smooth muscle relaxation
KW - theoretical study
UR - http://www.scopus.com/inward/record.url?scp=0017070417&partnerID=8YFLogxK
U2 - 10.1111/j.2042-7158.1976.tb02812.x
DO - 10.1111/j.2042-7158.1976.tb02812.x
M3 - Article
VL - 28
SP - 617
EP - 619
JO - Journal of Pharmacy and Pharmacology
JF - Journal of Pharmacy and Pharmacology
SN - 0022-3573
IS - 8
ER -