Actions of the muscle relaxant chandonium iodide on guinea‐pig ileum and vas deferens preparations

A. L. Harvey, Dharam Paul, I. W. Rodger, Harkishan Singh

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Abstract

The effects of the newly synthesized neuromuscular blocking agent, chandonium iodide (17a‐methyl‐3β‐pyrrolidino‐17a‐aza‐D‐homo‐5‐androstene dimethiodide) have been investigated on guinea‐pig isolated ileum and vas deferens preparations. On the ileum, chandonium (0·1–10·0 μg ml−1; 1·6 × 10−7m–1·;6 × 10−5m) had weak muscarinic receptor blocking action (pA2 is 5·7), but no antihistamine properties at the concentration tested. No evidence for anticholinesterase actions was found. On the vas deferens, chandonium (10·50 μg ml−1; 1·6–8·1 × 10−6 m) potentiated responses to exogenous noradrenaline; responses to electrical stimulation were potentiated only in the presence of 50 μg ml−1 chandonium. No adrenoceptor or adrenergic neuron blockade was found. The results provide evidence that chandonium acts selectively at acetylcholine receptors and that it is more active as a nicotinic receptor antagonist than as a muscarinic receptor antagonist.

Original languageEnglish
Pages (from-to)617-619
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume28
Issue number8
DOIs
Publication statusPublished - 1 Jan 1976

Keywords

  • acetylcholine
  • carbachol
  • cholinergic receptor
  • histamine
  • muscle relaxant agent
  • noradrenalin
  • chandonium iodide
  • dose response
  • drug response
  • ileum
  • in vitro study
  • smooth muscle contraction
  • smooth muscle relaxation
  • theoretical study

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