Actions of the muscle relaxant chandonium iodide on guinea‐pig ileum and vas deferens preparations

A. L. Harvey, Dharam Paul, I. W. Rodger, Harkishan Singh

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The effects of the newly synthesized neuromuscular blocking agent, chandonium iodide (17a‐methyl‐3β‐pyrrolidino‐17a‐aza‐D‐homo‐5‐androstene dimethiodide) have been investigated on guinea‐pig isolated ileum and vas deferens preparations. On the ileum, chandonium (0·1–10·0 μg ml−1; 1·6 × 10−7m–1·;6 × 10−5m) had weak muscarinic receptor blocking action (pA2 is 5·7), but no antihistamine properties at the concentration tested. No evidence for anticholinesterase actions was found. On the vas deferens, chandonium (10·50 μg ml−1; 1·6–8·1 × 10−6 m) potentiated responses to exogenous noradrenaline; responses to electrical stimulation were potentiated only in the presence of 50 μg ml−1 chandonium. No adrenoceptor or adrenergic neuron blockade was found. The results provide evidence that chandonium acts selectively at acetylcholine receptors and that it is more active as a nicotinic receptor antagonist than as a muscarinic receptor antagonist.

LanguageEnglish
Pages617-619
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume28
Issue number8
DOIs
Publication statusPublished - 1 Jan 1976

Fingerprint

Vas Deferens
Muscarinic Receptors
Ileum
Guinea Pigs
Androstenes
Nicotinic Antagonists
Neuromuscular Blocking Agents
Adrenergic Neurons
Muscles
Muscarinic Antagonists
Histamine Antagonists
Cholinesterase Inhibitors
Nicotinic Receptors
Cholinergic Receptors
Adrenergic Receptors
Electric Stimulation
Norepinephrine
chandonium iodide

Keywords

  • acetylcholine
  • carbachol
  • cholinergic receptor
  • histamine
  • muscle relaxant agent
  • noradrenalin
  • chandonium iodide
  • dose response
  • drug response
  • ileum
  • in vitro study
  • smooth muscle contraction
  • smooth muscle relaxation
  • theoretical study

Cite this

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title = "Actions of the muscle relaxant chandonium iodide on guinea‐pig ileum and vas deferens preparations",
abstract = "The effects of the newly synthesized neuromuscular blocking agent, chandonium iodide (17a‐methyl‐3β‐pyrrolidino‐17a‐aza‐D‐homo‐5‐androstene dimethiodide) have been investigated on guinea‐pig isolated ileum and vas deferens preparations. On the ileum, chandonium (0·1–10·0 μg ml−1; 1·6 × 10−7m–1·;6 × 10−5m) had weak muscarinic receptor blocking action (pA2 is 5·7), but no antihistamine properties at the concentration tested. No evidence for anticholinesterase actions was found. On the vas deferens, chandonium (10·50 μg ml−1; 1·6–8·1 × 10−6 m) potentiated responses to exogenous noradrenaline; responses to electrical stimulation were potentiated only in the presence of 50 μg ml−1 chandonium. No adrenoceptor or adrenergic neuron blockade was found. The results provide evidence that chandonium acts selectively at acetylcholine receptors and that it is more active as a nicotinic receptor antagonist than as a muscarinic receptor antagonist.",
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Actions of the muscle relaxant chandonium iodide on guinea‐pig ileum and vas deferens preparations. / Harvey, A. L.; Paul, Dharam; Rodger, I. W.; Singh, Harkishan.

In: Journal of Pharmacy and Pharmacology, Vol. 28, No. 8, 01.01.1976, p. 617-619.

Research output: Contribution to journalArticle

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