Actions of drugs on developing skeletal muscle

Alan L. Harvey

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Skeletal muscle development is outlined: myoblasts origin, myotube formation; development of myofibrils, T-tubules, sarcoplasmic reticulum and neuromuscular junctions; muscle growth, fiber types and 'neurotrophic' influences. Examples come from human and animal studies made in vivo and in tissue culture. Drug effects on early muscle development and tetratological actions are described. Acetylcholine receptor development is detailed, together with the sensitivity to nicotinic agonists and antagonists such as tubocurarine and α-bungarotoxin. Changes in receptor metabolism and ion channel properties are discussed. Development of electrical properties (resting membrane potential and action potential generation) and sensitivity to neurotoxins like tetrodotoxin is described.

Original languageEnglish
Pages (from-to)1-41
Number of pages41
JournalPharmacology and Therapeutics
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 1980

Keywords

  • 1,1 dimethyl 4 phenylpiperazinium
  • acetylcholine
  • alpha bungarotoxin
  • alpha bungarotoxin i 125
  • carbachol
  • cholinergic receptor
  • decamethonium
  • neostigmine
  • neurotoxin
  • nicotine
  • suxamethonium
  • tetramethylammonium
  • tetrodotoxin
  • tubocurarine chloride
  • animal experiment
  • drug efficacy
  • human cell
  • in vitro study
  • ion channel
  • muscle development
  • muscle fiber membrane potential
  • muscle fibril

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