Abstract
Skeletal muscle development is outlined: myoblasts origin, myotube formation; development of myofibrils, T-tubules, sarcoplasmic reticulum and neuromuscular junctions; muscle growth, fiber types and 'neurotrophic' influences. Examples come from human and animal studies made in vivo and in tissue culture. Drug effects on early muscle development and tetratological actions are described. Acetylcholine receptor development is detailed, together with the sensitivity to nicotinic agonists and antagonists such as tubocurarine and α-bungarotoxin. Changes in receptor metabolism and ion channel properties are discussed. Development of electrical properties (resting membrane potential and action potential generation) and sensitivity to neurotoxins like tetrodotoxin is described.
| Original language | English |
|---|---|
| Pages (from-to) | 1-41 |
| Number of pages | 41 |
| Journal | Pharmacology and Therapeutics |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Jan 1980 |
Keywords
- 1,1 dimethyl 4 phenylpiperazinium
- acetylcholine
- alpha bungarotoxin
- alpha bungarotoxin i 125
- carbachol
- cholinergic receptor
- decamethonium
- neostigmine
- neurotoxin
- nicotine
- suxamethonium
- tetramethylammonium
- tetrodotoxin
- tubocurarine chloride
- animal experiment
- drug efficacy
- human cell
- in vitro study
- ion channel
- muscle development
- muscle fiber membrane potential
- muscle fibril