ActDES – a curated actinobacterial database for evolutionary studies

Jana K. Schniete, Nelly Selem-Mojica, Anna S. Birke, Pablo Cruz-Morales, Iain S. Hunter, Francisco Barona-Gómez, Paul A. Hoskisson

Research output: Contribution to journalArticlepeer-review

Abstract

Actinobacteria is a large and diverse phylum of bacteria that contains medically and ecologically relevant organisms. Many members are valuable sources of bioactive natural products and chemical precursors that are exploited in the clinic and made using the enzyme pathways encoded in their complex genomes. Whilst the number of sequenced genomes has increased rapidly in the last twenty years, the large size, complexity and high G+C content of many Actinobacterial genomes means that the sequences remain incomplete and consist of large numbers of contigs with poor annotation, which hinders large scale comparative genomic and evolutionary studies. To enable greater understanding and exploitation of Actinobacterial genomes, specialised genomic databases must be linked to high-quality genome sequences. Here we provide a curated database of 612 high-quality actinobacterial genomes from 80 genera, chosen to represent a broad phylogenetic group with equivalent genome re-annotation. Utilising this database will provide researchers with a framework for evolutionary and metabolic studies, to enable a foundation for genome and metabolic engineering, to facilitate discovery of novel bioactive therapeutics and studies on gene family evolution.
Original languageEnglish
JournalMicrobial Genomics
Publication statusAccepted/In press - 8 Dec 2020

Keywords

  • Streptomyces
  • evolution
  • primary metabolism
  • specialised metabolism
  • antibiotics
  • natural product
  • biosynthetic gene cluster

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