A vasopressin-like peptide in the mammalian sympathetic nervous system

M R Hanley, H P Benton, S L Lightman, K Todd, E A Bone, P Fretten, S Palmer, C J Kirk, R H Michell

Research output: Contribution to journalArticle

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Abstract

Vasopressin was among the first mammalian hormonal peptides to be identified and to have its structure determined. Its only undisputed physiological role is as a circulating neurohypophyseal antidiuretic hormone. Other notable effects of vasopressin on peripheral tissues include contraction of vascular smooth muscle, leading to elevation of blood pressure, and activation of glycogenolysis in liver. It has long been clear that vascular smooth muscle and hepatocytes are relatively insensitive to the low concentrations of vasopressin normally present in the circulation, and the physiological significance of their responses has therefore been in doubt. We now report that a new bioactive and immunoreactive vasopressin-like peptide (VLP) is widely distributed in the sympathetic nervous system of mammals, both in the principal noradrenergic neurones of ganglia and in nerve fibres innervating peripheral tissues. In addition to other peptides described in the mammalian sympathetic nervous system, VLP must be considered as a possible mediator of the non-adrenergic responses to sympathetic activation. Moreover, many of the effects previously attributed to circulating vasopressin may be neurally evoked.

Original languageEnglish
Pages (from-to)258-61
Number of pages4
JournalNature
Volume309
Issue number5965
DOIs
Publication statusPublished - 17 May 1984

Fingerprint

Sympathetic Nervous System
Vasopressins
Peptides
Vascular Smooth Muscle
Posterior Pituitary Hormones
Glycogenolysis
Adrenergic Neurons
Nerve Fibers
Ganglia
Mammals
Hepatocytes
Blood Pressure
Liver

Keywords

  • animals
  • cross reactions
  • ganglia, sympathetic
  • inositol phosphates
  • molecular weight
  • oxytocin
  • rats
  • sympathetic nervous system
  • vasopressins

Cite this

Hanley, M. R., Benton, H. P., Lightman, S. L., Todd, K., Bone, E. A., Fretten, P., ... Michell, R. H. (1984). A vasopressin-like peptide in the mammalian sympathetic nervous system. Nature, 309(5965), 258-61. https://doi.org/10.1038/309258a0
Hanley, M R ; Benton, H P ; Lightman, S L ; Todd, K ; Bone, E A ; Fretten, P ; Palmer, S ; Kirk, C J ; Michell, R H. / A vasopressin-like peptide in the mammalian sympathetic nervous system. In: Nature. 1984 ; Vol. 309, No. 5965. pp. 258-61.
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Hanley, MR, Benton, HP, Lightman, SL, Todd, K, Bone, EA, Fretten, P, Palmer, S, Kirk, CJ & Michell, RH 1984, 'A vasopressin-like peptide in the mammalian sympathetic nervous system', Nature, vol. 309, no. 5965, pp. 258-61. https://doi.org/10.1038/309258a0

A vasopressin-like peptide in the mammalian sympathetic nervous system. / Hanley, M R; Benton, H P; Lightman, S L; Todd, K; Bone, E A; Fretten, P; Palmer, S; Kirk, C J; Michell, R H.

In: Nature, Vol. 309, No. 5965, 17.05.1984, p. 258-61.

Research output: Contribution to journalArticle

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AU - Michell, R H

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Hanley MR, Benton HP, Lightman SL, Todd K, Bone EA, Fretten P et al. A vasopressin-like peptide in the mammalian sympathetic nervous system. Nature. 1984 May 17;309(5965):258-61. https://doi.org/10.1038/309258a0