A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex

Andre Marques-Smith, Daniel Lyngholm, Anna-Kristin Kaufmann, Jacqueline A. Stacey, Anna Hoerder-Suabedissen, Esther B.E. Becker, Michael C. Wilson, Zoltán Molnár, Simon J.B. Butt

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.
LanguageEnglish
Pages536-549
Number of pages15
JournalNeuron
Volume89
Issue number3
DOIs
Publication statusPublished - 3 Feb 2016

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Somatosensory Cortex
Interneurons
Somatostatin
Neuregulin-1
Neocortex
Lasers
Population

Keywords

  • GABAergic activity
  • neocortical sensory circuits
  • laser-scanning photostimulation

Cite this

Marques-Smith, A., Lyngholm, D., Kaufmann, A-K., Stacey, J. A., Hoerder-Suabedissen, A., Becker, E. B. E., ... Butt, S. J. B. (2016). A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex. Neuron, 89(3), 536-549. https://doi.org/10.1016/j.neuron.2016.01.015
Marques-Smith, Andre ; Lyngholm, Daniel ; Kaufmann, Anna-Kristin ; Stacey, Jacqueline A. ; Hoerder-Suabedissen, Anna ; Becker, Esther B.E. ; Wilson, Michael C. ; Molnár, Zoltán ; Butt, Simon J.B. / A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex. In: Neuron. 2016 ; Vol. 89, No. 3. pp. 536-549.
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abstract = "GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.",
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Marques-Smith, A, Lyngholm, D, Kaufmann, A-K, Stacey, JA, Hoerder-Suabedissen, A, Becker, EBE, Wilson, MC, Molnár, Z & Butt, SJB 2016, 'A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex' Neuron, vol. 89, no. 3, pp. 536-549. https://doi.org/10.1016/j.neuron.2016.01.015

A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex. / Marques-Smith, Andre; Lyngholm, Daniel; Kaufmann, Anna-Kristin; Stacey, Jacqueline A. ; Hoerder-Suabedissen, Anna ; Becker, Esther B.E. ; Wilson, Michael C.; Molnár, Zoltán ; Butt, Simon J.B.

In: Neuron, Vol. 89, No. 3, 03.02.2016, p. 536-549.

Research output: Contribution to journalArticle

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AU - Marques-Smith, Andre

AU - Lyngholm, Daniel

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AU - Stacey, Jacqueline A.

AU - Hoerder-Suabedissen, Anna

AU - Becker, Esther B.E.

AU - Wilson, Michael C.

AU - Molnár, Zoltán

AU - Butt, Simon J.B.

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Marques-Smith A, Lyngholm D, Kaufmann A-K, Stacey JA, Hoerder-Suabedissen A, Becker EBE et al. A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex. Neuron. 2016 Feb 3;89(3):536-549. https://doi.org/10.1016/j.neuron.2016.01.015