TY - JOUR
T1 - A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex
AU - Marques-Smith, Andre
AU - Lyngholm, Daniel
AU - Kaufmann, Anna-Kristin
AU - Stacey, Jacqueline A.
AU - Hoerder-Suabedissen, Anna
AU - Becker, Esther B.E.
AU - Wilson, Michael C.
AU - Molnár, Zoltán
AU - Butt, Simon J.B.
PY - 2016/2/3
Y1 - 2016/2/3
N2 - GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.
AB - GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.
KW - GABAergic activity
KW - neocortical sensory circuits
KW - laser-scanning photostimulation
UR - http://www.sciencedirect.com/science/article/pii/S0896627316000167
U2 - 10.1016/j.neuron.2016.01.015
DO - 10.1016/j.neuron.2016.01.015
M3 - Article
SN - 0896-6273
VL - 89
SP - 536
EP - 549
JO - Neuron
JF - Neuron
IS - 3
ER -